{"id":"W2323633757","doi":"10.1006/mthe.2002.0608","title":"Baculoviral IAP Repeat-Containing-4 Protects Optic Nerve Axons in a Rat Glaucoma Model","year":2002,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":160,"is_retracted":false,"has_abstract":true,"ca_institutions":"Aegera Therapeutics (Canada); Children's Hospital of Eastern Ontario","funders":"National Eye Institute","keywords":"Optic nerve; Glaucoma; Intravitreal administration; Genetic enhancement; Retinal ganglion cell; Axon; Neuroprotection; Retinal; Biology; Retina; Intraocular pressure; Trabecular meshwork; Cell biology; Medicine; Ophthalmology; Pharmacology; Neuroscience; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002535245,0.0006497682,0.0004529674,0.0007793832,0.0002283425,0.0001764597,0.0002328852,0.0003674983,0.001515161],"category_scores_gemma":[0.0001302433,0.0002148052,0.000230534,0.0002079697,0.0003704293,0.0002598634,0.0001265856,0.0007350735,0.0003766587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002783057,"about_ca_system_score_gemma":0.0004953669,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001494893,"about_ca_topic_score_gemma":0.0025121,"domain_scores_codex":[0.9998521,0.00001611733,0.0000138751,0.00002319697,0.00004513309,0.0000496446],"domain_scores_gemma":[0.9998386,0.00001331831,0.0000428882,0.00002357535,0.00002018931,0.0000614837],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004248961,0.0002297131,0.0002386914,0.00004246239,0.00001083483,0.00007551706,0.00001755304,0.00002564315,0.9973047,0.00007277387,0.00007586766,0.001481424],"study_design_scores_gemma":[0.0001819955,0.006194817,0.005935986,0.00001735266,0.0000643239,0.0003675484,0.00004143,0.0006101102,0.9851189,0.0001070751,0.00135187,0.000008487635],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962722,0.001317136,0.0009989345,0.0001589544,0.00007261677,0.00005189671,0.0001893871,0.0001682384,0.0007706442],"genre_scores_gemma":[0.9888707,0.00206861,0.002829392,0.0001037282,0.00004049602,0.0001229602,0.0009455582,0.00003822906,0.004980286],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001515161,"threshold_uncertainty_score":0.00506866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01536229252081232,"score_gpt":0.2312035298238709,"score_spread":0.2158412373030585,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}