{"id":"W2323656618","doi":"10.1021/sb5003218","title":"Expansion of Bisindole Biosynthetic Pathways by Combinatorial Construction","year":2014,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Genome British Columbia; Michael Smith Health Research BC","keywords":"Natural product; Computational biology; Glycosyltransferase; Gene; Synthetic biology; Biology; Enzyme; Drug discovery; Substrate specificity; Biochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000252352,0.0004650871,0.0003219395,0.0007052362,0.000191347,0.000614056,0.0005182551,0.000267081,0.001012768],"category_scores_gemma":[0.0002489592,0.0002934579,0.0004148888,0.0006309171,0.0002565342,0.0003042804,0.0007279551,0.0008530722,0.0004664577],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004851448,"about_ca_system_score_gemma":0.0004068592,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004353454,"about_ca_topic_score_gemma":0.001186577,"domain_scores_codex":[0.9997284,0.00004131594,0.00002580281,0.00006061582,0.00008803559,0.00005578587],"domain_scores_gemma":[0.9998241,0.00002687804,0.00004292994,0.00003113901,0.00002640864,0.00004856524],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001560675,0.00014512,0.0004425308,0.0001091676,0.00001864823,0.0001962325,0.00006697885,0.002163346,0.9747152,0.0030455,0.0001900662,0.01875115],"study_design_scores_gemma":[0.00005328589,0.0004390488,0.0009326167,0.00001730641,0.00005001828,0.0003583286,0.00004327644,0.009083563,0.9704264,0.0006255127,0.01794747,0.00002321771],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8548741,0.00125328,0.1281548,0.0002310635,0.0001153846,0.0006086044,0.001183029,0.0009352265,0.0126444],"genre_scores_gemma":[0.8834371,0.001586717,0.1083359,0.0001016981,0.00001684555,0.0004767533,0.00217754,0.0001833038,0.003684139],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001012768,"threshold_uncertainty_score":0.003520012,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009914680860927255,"score_gpt":0.224977074734164,"score_spread":0.2150623938732367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}