{"id":"W2323656618","doi":"10.1021/sb5003218","title":"Expansion of Bisindole Biosynthetic Pathways by Combinatorial Construction","year":2014,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Genome British Columbia; Michael Smith Health Research BC","keywords":"Natural product; Computational biology; Glycosyltransferase; Gene; Synthetic biology; Biology; Enzyme; Drug discovery; Substrate specificity; Biochemistry; Chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003733096,0.0001919759,0.0005019541,0.000116576,0.00007177376,0.00000571294,0.0001325881,0.0003269346,0.0001873928],"category_scores_gemma":[0.0005997838,0.0001377089,0.0001048148,0.0001670404,0.00051127,0.00002868904,0.00005891465,0.0001777679,0.00004727923],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002748049,"about_ca_system_score_gemma":0.00004925573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005305724,"about_ca_topic_score_gemma":7.469996e-7,"domain_scores_codex":[0.9986803,0.0001340554,0.0003903176,0.000399483,0.0001136527,0.0002821763],"domain_scores_gemma":[0.9989611,0.000192804,0.0001868804,0.0004304947,0.00013629,0.00009245635],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001526693,0.0001046864,0.0004025645,0.00005024857,0.00003022784,6.334228e-7,0.00002921636,6.524304e-8,0.934519,0.01128073,0.0007503403,0.05267962],"study_design_scores_gemma":[0.0008970381,0.000666867,0.0001400694,0.0000967098,0.00009051157,0.0001065038,0.00003611087,0.00002073315,0.9696457,0.00434079,0.02379524,0.0001637067],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950752,0.0003221069,0.0001847825,0.001509928,0.001221043,0.0002714225,0.00004398043,0.00006397637,0.001307514],"genre_scores_gemma":[0.9985458,0.0001076777,0.0008264814,0.0001946335,0.000209146,0.000001473323,0.00004168563,0.00001983395,0.00005331054],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05251592,"threshold_uncertainty_score":0.5615607,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009914680860927255,"score_gpt":0.224977074734164,"score_spread":0.2150623938732367,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}