{"id":"W2323746005","doi":"10.1038/sj.onc.1204679","title":"Conserved synteny between the Fugu and human PTEN locus and the evolutionary conservation of vertebrate PTEN function","year":2001,"lang":"en","type":"article","venue":"Oncogene","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Children's & Women's Health Centre of British Columbia; University of British Columbia","funders":"Medical Research Council; National Science Board","keywords":"Biology; Synteny; PTEN; Fugu; Vertebrate; Locus (genetics); Conserved sequence; Evolutionary biology; Genetics; Function (biology); Gene; Genome; Base sequence","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003473868,0.0001105834,0.0001435368,0.00001882339,0.0001788678,0.00001606501,0.0001141645,0.0001034881,0.00002037967],"category_scores_gemma":[0.00005477883,0.00007176292,0.00004438552,0.00007456439,0.000448546,0.000005433301,0.00008329495,0.00007067335,0.000001919709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001315734,"about_ca_system_score_gemma":0.00005149809,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002344586,"about_ca_topic_score_gemma":0.00009430972,"domain_scores_codex":[0.9992244,0.0001273238,0.0001978845,0.0002102303,0.0001114951,0.0001286381],"domain_scores_gemma":[0.9994069,0.00006324489,0.0001234929,0.0002577643,0.0001126301,0.00003598816],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005734384,0.00002856261,0.1428518,0.00002698614,0.0002982557,0.000002210488,0.0000681517,0.00003344002,0.8465735,0.0005804814,0.004478269,0.004484871],"study_design_scores_gemma":[0.01469259,0.001888281,0.4443457,0.0002025158,0.001246613,0.0002507266,0.0006039586,0.00297473,0.3490424,0.007903034,0.175701,0.001148354],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923189,0.004677661,0.0006081766,0.001491162,0.00008049342,0.0002001471,0.00002538811,0.000008669203,0.0005894426],"genre_scores_gemma":[0.9984161,0.0003372095,0.0000449361,0.000534246,0.0002285684,0.00002300531,0.00007350076,0.00001303523,0.0003294353],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4975311,"threshold_uncertainty_score":0.2926407,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01477275729120362,"score_gpt":0.2458267390712314,"score_spread":0.2310539817800278,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}