{"id":"W2323767515","doi":"10.1158/1535-7163.targ-09-a188","title":"Abstract A188: Proapoptotic <i>versus</i> prosurvival function of the MAP kinase p38 induced by HDAC inhibitor in hematological malignant cells","year":2009,"lang":"en","type":"article","venue":"Molecular Cancer Therapeutics","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital","funders":"","keywords":"Vorinostat; Histone deacetylase inhibitor; Sodium butyrate; DNA damage; Apoptosis; p38 mitogen-activated protein kinases; Cell cycle; Biology; Cell cycle checkpoint; Histone deacetylase; Cancer research; Cell biology; Kinase; Chemistry; Histone; Cell culture; Protein kinase A; Biochemistry; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005695249,0.0002809922,0.0001951658,0.0001542333,0.0001085625,0.000150594,0.0001087116,0.0001334661,0.003772726],"category_scores_gemma":[0.0000552024,0.00005999613,0.0001767406,0.0001152692,0.0001206022,0.0001382773,0.00006859148,0.0003870278,0.0004575614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001339669,"about_ca_system_score_gemma":0.0001097729,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002792956,"about_ca_topic_score_gemma":0.0002273104,"domain_scores_codex":[0.9999443,0.000008724758,0.00000520158,0.000009421116,0.00001469994,0.00001758524],"domain_scores_gemma":[0.9999647,0.000007055373,0.000009094622,0.000003715085,0.000004280374,0.0000111962],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004263061,0.00005537122,0.0001575563,0.00005709137,0.00000535255,0.00008699676,0.000008928208,0.0000311306,0.9973278,0.00008735441,0.0001334575,0.001622599],"study_design_scores_gemma":[0.00005230108,0.0009112736,0.003593273,0.000005019924,0.00001451972,0.0002913286,0.00002258461,0.0003183518,0.9923148,0.00005544245,0.002419041,0.000002189901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907865,0.003210806,0.001362696,0.0001952406,0.00009652704,0.00003917431,0.0007848439,0.0001355498,0.003388755],"genre_scores_gemma":[0.9944741,0.001049637,0.000892307,0.00006855124,0.00003691046,0.00004188459,0.0007967443,0.0000149325,0.002624978],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003772726,"threshold_uncertainty_score":0.01262105,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02272329774206789,"score_gpt":0.2864238494424917,"score_spread":0.2637005517004238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}