{"id":"W2323831336","doi":"10.1021/acs.biochem.5b00177","title":"Role of Positively Charged Residues of the Second Transmembrane Domain in the Ion Transport Activity and Conformation of Human Uncoupling Protein-2","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"Wilfrid Laurier University; University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; Canada Foundation for Innovation","keywords":"Chemistry; Transmembrane domain; Intermembrane space; Biophysics; Transmembrane protein; Biochemistry; Mitochondrion; Transport protein; Ion transporter; Uncoupling protein; Inner mitochondrial membrane; Membrane potential; Amino acid; Membrane; Biology; Bacterial outer membrane; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001293763,0.0002731284,0.0001867957,0.0001109814,0.0001342069,0.0001876138,0.0001999195,0.0003141868,0.0005784768],"category_scores_gemma":[0.0002309148,0.0001039728,0.0003018449,0.0001288034,0.0001967225,0.0001807185,0.0001908101,0.0002692044,0.0002943024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001970942,"about_ca_system_score_gemma":0.0001349862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006015707,"about_ca_topic_score_gemma":0.0003705369,"domain_scores_codex":[0.999895,0.00002369483,0.00001200013,0.00002498752,0.00002492788,0.00001943011],"domain_scores_gemma":[0.9998512,0.00002953745,0.0000509556,0.00001257946,0.00001414489,0.00004141061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001941697,0.00002293409,0.001177838,0.0000276687,0.000008757572,0.0004534943,0.00003750235,0.0002183076,0.9968977,0.000119192,0.00003887567,0.0008034515],"study_design_scores_gemma":[0.0001002296,0.0002817589,0.04091636,0.00001938952,0.00005814136,0.003652315,0.0001509904,0.004830331,0.9460723,0.0001976371,0.00368857,0.00003187211],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983791,0.0004435084,0.000742415,0.0001025562,0.00001401653,0.000004469899,0.00007951152,0.00001042242,0.0002240159],"genre_scores_gemma":[0.997977,0.000252895,0.0008840627,0.00006217723,0.000008786882,0.000007493782,0.000299376,0.000006800306,0.0005013046],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006015707,"threshold_uncertainty_score":0.001935124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01365097940275248,"score_gpt":0.2522545744615095,"score_spread":0.238603595058757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}