{"id":"W2323908823","doi":"10.1385/ir:35:1:117","title":"Human T Cell Immunodeficiency: When Signal Transduction Goes Wrong","year":2006,"lang":"en","type":"review","venue":"Immunologic Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Severe combined immunodeficiency; Immunology; Immunodeficiency; Biology; Signal transduction; Immune system; T cell; Haematopoiesis; Stem cell; Primary immunodeficiency; Transduction (biophysics); Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":["research_integrity","insufficient_payload"],"category_scores_codex":[0.00243965,0.0008169478,0.001835822,0.001459206,0.001683604,0.0002100415,0.001445894,0.002009943,0.01549244],"category_scores_gemma":[0.00008438127,0.0006454315,0.00102617,0.0008340011,0.001085465,0.0003271602,0.000353332,0.005174173,0.01219335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007444294,"about_ca_system_score_gemma":0.00043207,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001016127,"about_ca_topic_score_gemma":0.000009880346,"domain_scores_codex":[0.9919614,0.00352707,0.001496027,0.001197634,0.0002743076,0.001543524],"domain_scores_gemma":[0.9972762,0.0005354711,0.0005177144,0.001193958,0.0004473077,0.0000293795],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001010149,0.001110605,0.000002673791,0.003503231,0.000570093,0.0000289424,0.0003031072,0.00000359821,0.04250313,0.0005448026,0.09734766,0.8539811],"study_design_scores_gemma":[0.0005821253,0.0007279441,0.00001371012,0.001517926,0.0002203888,0.0002051825,0.000311501,5.219973e-7,0.002097192,0.0001830682,0.993521,0.000619489],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001532162,0.9593734,0.00005007625,0.00004296168,0.003655391,0.001347941,0.00002293639,0.0002897895,0.03506435],"genre_scores_gemma":[0.001252135,0.8271168,0.00001775553,0.00001047977,0.0001343941,0.0003788159,0.001230336,0.00009749372,0.1697618],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.8961733,"threshold_uncertainty_score":0.9996161,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1319931086113766,"score_gpt":0.3924929474839879,"score_spread":0.2604998388726113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}