{"id":"W2323908823","doi":"10.1385/ir:35:1:117","title":"Human T Cell Immunodeficiency: When Signal Transduction Goes Wrong","year":2006,"lang":"en","type":"review","venue":"Immunologic Research","topic":"Immune Cell Function and Interaction","field":"Immunology and Microbiology","cited_by":19,"is_retracted":false,"has_abstract":false,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"","keywords":"Severe combined immunodeficiency; Immunology; Immunodeficiency; Biology; Signal transduction; Immune system; T cell; Haematopoiesis; Stem cell; Primary immunodeficiency; Transduction (biophysics); Cell biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009190632,0.001413636,0.002049767,0.001418707,0.0002939709,0.001376191,0.001377876,0.002544872,0.001882479],"category_scores_gemma":[0.0009635446,0.000286815,0.0003285686,0.001579183,0.001285012,0.002082194,0.0006366625,0.003166241,0.002340579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006977128,"about_ca_system_score_gemma":0.0009984748,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007712094,"about_ca_topic_score_gemma":0.001092509,"domain_scores_codex":[0.9997572,0.00003944348,0.00004319074,0.00004217985,0.00008852045,0.00002940001],"domain_scores_gemma":[0.9995704,0.0001889733,0.00005326666,0.0000171425,0.00011077,0.00005935851],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001468322,0.00005672219,0.0001681416,0.005937528,0.00004781373,0.0004958963,0.00004710235,0.0002137317,0.003624609,0.004421469,0.1000531,0.8847871],"study_design_scores_gemma":[0.00003534774,0.00007327989,0.0003988504,0.001648425,0.00009672392,0.002110351,0.00006684585,0.00005988304,0.0008966857,0.003582706,0.9910157,0.00001522165],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0000712852,0.9971666,0.0002413913,0.0007765318,0.001135265,0.000002375398,0.000009658671,0.00001243235,0.0005845233],"genre_scores_gemma":[0.0006987462,0.9955317,0.0003361233,0.001021564,0.001462005,0.000007645414,0.00002597802,0.000002793171,0.0009134391],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002544872,"threshold_uncertainty_score":0.006297588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1319931086113766,"score_gpt":0.3924929474839879,"score_spread":0.2604998388726113,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}