{"id":"W2324038639","doi":"10.1021/bi101808h","title":"Mechanistic Evaluation of <i>MelA</i> α-Galactosidase from <i>Citrobacter freundii</i>: A Family 4 Glycosyl Hydrolase in Which Oxidation Is Rate-Limiting","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Chemistry; Citrobacter freundii; Hydrolase; Kinetic isotope effect; Glycosyl; Stereochemistry; Hydrolysis; Substrate (aquarium); Enzyme kinetics; Enzyme; Escherichia coli; Active site; Deuterium; Biochemistry; Enterobacteriaceae; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006018557,0.0002192661,0.0002118752,0.00005391613,0.00004077884,0.00002009807,0.0002104179,0.0002877642,0.0001352105],"category_scores_gemma":[0.0004174569,0.000234189,0.00009127667,0.000242989,0.00004008523,0.00001836809,0.0000833133,0.0001006022,0.00001130428],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005125532,"about_ca_system_score_gemma":0.0001796765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001238216,"about_ca_topic_score_gemma":0.000055712,"domain_scores_codex":[0.998368,0.0001161034,0.000465506,0.0005475961,0.000280364,0.0002224835],"domain_scores_gemma":[0.9986446,0.00001926543,0.0002777112,0.0005789346,0.0004036061,0.00007581039],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00010889,0.0001514935,0.003451568,0.00003248563,0.00004324908,7.858469e-7,0.0001305122,0.00001415824,0.9955877,0.00000604665,0.0001679878,0.0003051189],"study_design_scores_gemma":[0.001005005,0.00006049909,0.006141418,0.00006152868,0.0001228289,0.000001567991,0.0001289567,0.001356105,0.9906631,0.0001221326,0.00009434579,0.0002425511],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996249,0.0004636809,0.00133382,0.00001398713,0.00007675887,0.0002163311,0.0001002514,0.00001164082,0.001534498],"genre_scores_gemma":[0.9971357,0.00008896651,0.0004349367,0.000168661,0.0001124107,0.00005372898,0.001918374,0.000028775,0.00005843828],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004924642,"threshold_uncertainty_score":0.9549952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02755290409754402,"score_gpt":0.2451418560144246,"score_spread":0.2175889519168806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}