{"id":"W2324038639","doi":"10.1021/bi101808h","title":"Mechanistic Evaluation of <i>MelA</i> α-Galactosidase from <i>Citrobacter freundii</i>: A Family 4 Glycosyl Hydrolase in Which Oxidation Is Rate-Limiting","year":2011,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Chemistry; Citrobacter freundii; Hydrolase; Kinetic isotope effect; Glycosyl; Stereochemistry; Hydrolysis; Substrate (aquarium); Enzyme kinetics; Enzyme; Escherichia coli; Active site; Deuterium; Biochemistry; Enterobacteriaceae; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003225936,0.0006288994,0.0002867321,0.00008727184,0.0002191146,0.0003798814,0.0005116994,0.0004069388,0.0007101748],"category_scores_gemma":[0.0002847644,0.0001209192,0.0003182686,0.0001212216,0.0002614101,0.0004969579,0.0002323317,0.0007223606,0.0002358492],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008339174,"about_ca_system_score_gemma":0.0003672911,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002482832,"about_ca_topic_score_gemma":0.002443276,"domain_scores_codex":[0.9998649,0.00002236261,0.000006126579,0.00002268935,0.00003436583,0.00004961187],"domain_scores_gemma":[0.9999148,0.00001729365,0.00001736983,0.000006776308,0.00002519106,0.0000185452],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003309701,0.00009791725,0.001053716,0.0002450979,0.00001936059,0.0001320851,0.00005118072,0.001551496,0.9923149,0.0005407259,0.0001376219,0.003524932],"study_design_scores_gemma":[0.00001254531,0.0003512052,0.001334209,0.00001169171,0.00001195929,0.0001178839,0.00006014282,0.00281755,0.9923748,0.0001210067,0.002776229,0.00001079012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9872498,0.002076798,0.005785963,0.0002454396,0.00003215576,0.00008910164,0.0004624975,0.0000721976,0.00398613],"genre_scores_gemma":[0.9958199,0.0008324155,0.002275352,0.00004571909,0.000002981825,0.00002362549,0.0002763387,0.00001435455,0.0007093169],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002482832,"threshold_uncertainty_score":0.006050467,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02755290409754402,"score_gpt":0.2451418560144246,"score_spread":0.2175889519168806,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}