{"id":"W2324231769","doi":"10.1371/journal.pone.0153304","title":"High Physiological Concentrations of Progesterone Reverse Estradiol-Mediated Changes in Differentiation and Functions of Bone Marrow Derived Dendritic Cells","year":2016,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Institute of Infection and Immunity; Canadian Institutes of Health Research; Ontario HIV Treatment Network","keywords":"CD11c; Dendritic cell; Immune system; Hormone; Biology; Bone marrow; Cellular differentiation; Integrin alpha M; CD40; Myeloid; Cell biology; MHC class II; Endocrinology; Internal medicine; Immunology; Chemistry; T cell; Biochemistry; Medicine; Cytotoxic T cell; In vitro; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008077398,0.00009149444,0.0003368565,0.00006608879,0.0000303517,0.000001788604,0.00004311214,0.0001207289,0.0001738827],"category_scores_gemma":[0.0001082558,0.00006439023,0.00002212653,0.0000789374,0.000215432,0.00005995697,0.00002180517,0.00006247896,0.00002102862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001495473,"about_ca_system_score_gemma":0.00001604196,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000252948,"about_ca_topic_score_gemma":0.00003875743,"domain_scores_codex":[0.9991428,0.0002055932,0.0002609176,0.0002147959,0.00003296922,0.0001429441],"domain_scores_gemma":[0.9994507,0.0001266872,0.0001584453,0.000167506,0.0000825422,0.00001404711],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004454545,0.0006212147,0.02759218,0.0001227863,0.0001416322,7.253236e-7,0.0001640256,1.818402e-7,0.9710104,0.0001242668,0.00003078621,0.0001473004],"study_design_scores_gemma":[0.0009633991,0.0002482672,0.2385063,0.0004195206,0.00007003803,0.000002341902,0.00005887056,4.058476e-7,0.7595974,0.0000652856,0.000004146961,0.00006410694],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971738,0.001785408,0.00004299484,0.0003495691,0.00009871976,0.0004003836,0.0001160666,0.00001724511,0.00001584542],"genre_scores_gemma":[0.9991003,0.0003153408,0.00009781786,0.000007280402,0.0000179676,0.00005403745,0.00006999603,0.000005672595,0.00033162],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.211413,"threshold_uncertainty_score":0.2625757,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03081489079549907,"score_gpt":0.2035061309130647,"score_spread":0.1726912401175656,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}