{"id":"W2324268404","doi":"10.1021/cn500193f","title":"Syntheses and Evaluation of Carbon-11- and Fluorine-18-Radiolabeled pan-Tropomyosin Receptor Kinase (Trk) Inhibitors: Exploration of the 4-Aza-2-oxindole Scaffold as Trk PET Imaging Agents","year":2014,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Montreal Neurological Institute and Hospital; Douglas Mental Health University Institute; McGill University; University of Alberta","funders":"Canada Foundation for Innovation","keywords":"Trk receptor; Tropomyosin; Oxindole; Chemistry; Kinase; Pharmacology; Tropomyosin receptor kinase A; Receptor; Cancer research; Biochemistry; Medicine; Neurotrophin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002959566,0.0006458816,0.0005299483,0.0003333801,0.000191436,0.0002386059,0.0006249302,0.0004822012,0.001239455],"category_scores_gemma":[0.0002126076,0.0002748849,0.0003509802,0.0003551768,0.0001794987,0.0003901229,0.0002509996,0.0005565428,0.0008465645],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004214128,"about_ca_system_score_gemma":0.0003273164,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005391686,"about_ca_topic_score_gemma":0.001334705,"domain_scores_codex":[0.9998509,0.00002797306,0.00001539621,0.00002976246,0.00003746105,0.0000385515],"domain_scores_gemma":[0.9998952,0.00001254031,0.00002760892,0.0000107245,0.00002210414,0.0000318053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002803505,0.0002137726,0.0001203956,0.000534492,0.00003706205,0.0004239439,0.00009794871,0.003046833,0.9801816,0.0009010461,0.0004369864,0.01372561],"study_design_scores_gemma":[0.0001202093,0.001944315,0.0005918369,0.00003059316,0.00005766505,0.0006108374,0.00002697058,0.002306605,0.980091,0.0001157133,0.01406643,0.00003769352],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9134145,0.0247413,0.04447856,0.0003566593,0.00015546,0.001296166,0.002289552,0.0005278417,0.01273988],"genre_scores_gemma":[0.9435368,0.01690122,0.03138886,0.0001327002,0.00004714119,0.0005006079,0.001737219,0.00008984128,0.005665648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001239455,"threshold_uncertainty_score":0.004146397,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07076252528135317,"score_gpt":0.3507855952758984,"score_spread":0.2800230699945452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}