{"id":"W2324268404","doi":"10.1021/cn500193f","title":"Syntheses and Evaluation of Carbon-11- and Fluorine-18-Radiolabeled pan-Tropomyosin Receptor Kinase (Trk) Inhibitors: Exploration of the 4-Aza-2-oxindole Scaffold as Trk PET Imaging Agents","year":2014,"lang":"en","type":"article","venue":"ACS Chemical Neuroscience","topic":"HER2/EGFR in Cancer Research","field":"Medicine","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; Montreal Neurological Institute and Hospital; Douglas Mental Health University Institute; McGill University; University of Alberta","funders":"Canada Foundation for Innovation","keywords":"Trk receptor; Tropomyosin; Oxindole; Chemistry; Kinase; Pharmacology; Tropomyosin receptor kinase A; Receptor; Cancer research; Biochemistry; Medicine; Neurotrophin","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001155219,0.0001506643,0.0002674987,0.00008931457,0.00007619767,0.00003516809,0.0002253916,0.000043893,0.00001601899],"category_scores_gemma":[0.00599211,0.0001136178,0.00003951524,0.0004680794,0.000713848,0.0002397283,0.0002020955,0.0001705357,8.848961e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008796637,"about_ca_system_score_gemma":0.0001860606,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001729558,"about_ca_topic_score_gemma":0.00000384924,"domain_scores_codex":[0.9973972,0.00025966,0.0003464309,0.0004668992,0.001258237,0.0002715903],"domain_scores_gemma":[0.9987071,0.000285383,0.0001625349,0.0004207579,0.0002733752,0.0001508304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004839267,0.00008257751,0.01551714,0.00008948716,0.000002040023,0.000001473373,0.0001629934,0.00000366649,0.9774941,0.00003550333,0.0001901659,0.00637246],"study_design_scores_gemma":[0.000819665,0.0001276547,0.003725869,0.0003656278,0.00004740313,0.00002807198,0.00008228279,0.009906276,0.9844329,0.0001372458,0.0002272868,0.00009975331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9973889,0.0001297076,0.000007875684,0.001462089,0.0001978151,0.000556864,0.000006145981,0.0000181465,0.0002324748],"genre_scores_gemma":[0.9994304,0.00008251437,0.0001179553,0.000175253,0.0001039795,0.00004256041,0.000002285496,0.00001856451,0.00002648082],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01179127,"threshold_uncertainty_score":0.7173548,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07076252528135317,"score_gpt":0.3507855952758984,"score_spread":0.2800230699945452,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}