{"id":"W2324276018","doi":"10.1016/j.dadm.2016.03.001","title":"White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration","year":2016,"lang":"en","type":"article","venue":"Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring","topic":"Dementia and Cognitive Impairment Research","field":"Medicine","cited_by":94,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Biomedical Imaging and Bioengineering; National Institute on Aging; National Institutes of Health; Canadian Institutes of Health Research; Weston Brain Institute; Genentech; Pfizer; Novartis Pharmaceuticals Corporation; National Institute of Environmental Health Sciences; Servier; GE Healthcare; BioClinica; Takeda Pharmaceutical Company; Eli Lilly and Company; Norman Cousins Center for Psychoneuroimmunology; Merck; U.S. Department of Defense","keywords":"Hyperintensity; Neuroimaging; Medicine; Apolipoprotein E; Neurodegeneration; Cohort; White matter; Cerebrospinal fluid; Alzheimer's Disease Neuroimaging Initiative; Internal medicine; Brain size; Alzheimer's disease; Magnetic resonance imaging; Oncology; Effects of sleep deprivation on cognitive performance; Pathology; Disease; Cognition; Radiology; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006771984,0.0003825875,0.0003159266,0.0009217585,0.0002162562,0.0005663038,0.0002553227,0.0002697511,0.002276766],"category_scores_gemma":[0.002473418,0.0001883266,0.0001750056,0.000634542,0.0004159275,0.000376957,0.0003026844,0.000307033,0.0002834863],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001554306,"about_ca_system_score_gemma":0.0002076751,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0007541099,"about_ca_topic_score_gemma":0.001411391,"domain_scores_codex":[0.9997439,0.00006051672,0.00003035728,0.00008119723,0.00006291574,0.00002103718],"domain_scores_gemma":[0.9977563,0.0003221251,0.001570056,0.00008349438,0.0001363199,0.0001317446],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002201415,0.00005774889,0.992018,0.0000371567,0.0001403716,0.0001257441,0.00005832851,0.00003991841,0.002181335,0.00003754926,0.00009869693,0.004984988],"study_design_scores_gemma":[0.000004458085,0.00006940505,0.9990269,0.000005873588,0.0000246412,0.0003405984,0.00002661388,0.00003854979,0.0003314219,0.00006057427,0.00006969828,0.000001404114],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998478,0.0006569281,0.000123017,0.00004929919,0.000004931351,0.000004881179,0.0001039473,0.000007192317,0.0005717531],"genre_scores_gemma":[0.9991575,0.0002133769,0.000217115,0.00002860805,0.00002502051,0.000003513041,0.0001932716,0.000002276516,0.0001593748],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002276766,"threshold_uncertainty_score":0.00761658,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02796673263103714,"score_gpt":0.3276047608555305,"score_spread":0.2996380282244933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}