{"id":"W2324384200","doi":"10.1021/jo301638z","title":"Total Synthesis of Pactamycin and Pactamycate: A Detailed Account","year":2012,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Chemistry; Oxazoline; Total synthesis; Stereochemistry; Moiety; Cyclopentanone; Cyclopentenone; Epoxide; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001287249,0.0006973449,0.0004670439,0.0005999877,0.0004877732,0.0003359346,0.0003788542,0.0002491178,0.006151835],"category_scores_gemma":[0.0001558159,0.0002076658,0.0002418689,0.0006884122,0.0001510334,0.0007477201,0.0003919461,0.0007354677,0.004686667],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003481886,"about_ca_system_score_gemma":0.0007712267,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006091566,"about_ca_topic_score_gemma":0.001349245,"domain_scores_codex":[0.9998657,0.00001102115,0.00001289846,0.00002881695,0.00005320226,0.00002850519],"domain_scores_gemma":[0.9999479,0.000005819661,0.000007486673,0.00001173328,0.0000160011,0.00001100245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001530536,0.0001265785,0.000205963,0.001067913,0.00004302922,0.0005514915,0.000170371,0.001316424,0.8635975,0.003864326,0.002610352,0.1262931],"study_design_scores_gemma":[0.00002550873,0.0004742045,0.0009941929,0.00005654283,0.00006418199,0.001551311,0.00004920675,0.000895629,0.76351,0.0009766488,0.2313576,0.00004500869],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.3704247,0.07272951,0.3233225,0.001275538,0.001052037,0.003416752,0.01291482,0.003515712,0.2113483],"genre_scores_gemma":[0.6660683,0.09065324,0.1588466,0.0005325276,0.0003338271,0.00143005,0.01000204,0.0009006494,0.07123281],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006151835,"threshold_uncertainty_score":0.02057993,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007913607440481807,"score_gpt":0.2186810283855206,"score_spread":0.2107674209450388,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}