{"id":"W2324404021","doi":"10.1136/annrheumdis-2012-eular.1852","title":"OP0169 Sarilumab for the treatment of ankylosing spondylitis: Results of a phase 2, randomized. Double-blind, placebo-controlled, international study (align)","year":2012,"lang":"en","type":"article","venue":"Annals of the Rheumatic Diseases","topic":"Spondyloarthritis Studies and Treatments","field":"Medicine","cited_by":34,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Western Hospital","funders":"","keywords":"Medicine; Ankylosing spondylitis; Placebo; Clinical endpoint; Concomitant; Internal medicine; Regimen; Adverse effect; Gastroenterology; Randomized controlled trial","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003992885,0.003198139,0.004745188,0.0008333813,0.0008361453,0.001552472,0.00131044,0.002802458,0.007664112],"category_scores_gemma":[0.002260759,0.00141819,0.003175497,0.0007863482,0.001836425,0.00188795,0.0005949005,0.004561815,0.001819993],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006332838,"about_ca_system_score_gemma":0.001304094,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00111956,"about_ca_topic_score_gemma":0.002523681,"domain_scores_codex":[0.9987816,0.0006005914,0.0001009886,0.0001994421,0.0001150342,0.0002023955],"domain_scores_gemma":[0.9987574,0.0003549668,0.0003372072,0.0001226282,0.00009263901,0.000335209],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9762914,0.007174793,0.0005670618,0.0007824774,0.0009572989,0.00004316092,0.0000551197,0.0001136539,0.002875019,0.0000700076,0.0006746612,0.0103954],"study_design_scores_gemma":[0.9749913,0.02289986,0.001133447,0.0000153174,0.0004431516,0.00002567854,0.00001355361,0.00006694621,0.0001621322,0.00003018248,0.0002083173,0.0000100441],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9795131,0.007353357,0.001164,0.001045897,0.0008747088,0.003887871,0.002808148,0.0003274117,0.003025474],"genre_scores_gemma":[0.9655894,0.007938159,0.00460629,0.002989616,0.001805205,0.006183024,0.004889853,0.0001450273,0.005853415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007664112,"threshold_uncertainty_score":0.025639,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08510372261674753,"score_gpt":0.3927855748835677,"score_spread":0.3076818522668202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}