{"id":"W2324487154","doi":"10.1006/mthe.2001.0435","title":"Challenges and Strategies for Cystic Fibrosis Lung Gene Therapy","year":2001,"lang":"en","type":"review","venue":"Molecular Therapy","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre; SickKids Foundation; University of Toronto; Hospital for Sick Children; Canadian Institutes of Health Research","funders":"","keywords":"Genetic enhancement; Cystic fibrosis; Transgene; Gene delivery; Biology; Lung; Gene; Gene expression; Gene transfer; Immunology; Bioinformatics; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003065105,0.001316682,0.002368147,0.003053788,0.0009423703,0.002693421,0.001678549,0.00344931,0.004396661],"category_scores_gemma":[0.002386061,0.0004145964,0.000740215,0.002381417,0.002155037,0.00464636,0.001364144,0.005558946,0.002766417],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001948512,"about_ca_system_score_gemma":0.002296097,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002476408,"about_ca_topic_score_gemma":0.005866512,"domain_scores_codex":[0.9994659,0.0001581838,0.00005602122,0.00007013165,0.0001980851,0.00005170257],"domain_scores_gemma":[0.9986338,0.0009150655,0.00007754962,0.00003751095,0.0002490842,0.00008707015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001458206,0.0001494609,0.0002219411,0.008238627,0.00006900357,0.0005339943,0.00018451,0.0008348255,0.001774687,0.02866108,0.09136291,0.8678231],"study_design_scores_gemma":[0.00002718053,0.00005734331,0.0001901277,0.001839061,0.00003160092,0.0007061317,0.0001115557,0.00009217276,0.0001664604,0.005015169,0.9917492,0.00001399481],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.00005096856,0.9959937,0.0002960881,0.001680829,0.0007089584,0.000003960846,0.000005006859,0.000007189512,0.001253251],"genre_scores_gemma":[0.0003735455,0.9960203,0.0006260556,0.001150812,0.0006239712,0.0000121967,0.0000122341,0.000002321264,0.001178615],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.004396661,"threshold_uncertainty_score":0.01621002,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1739721155908137,"score_gpt":0.451721800001982,"score_spread":0.2777496844111683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}