{"id":"W2324487154","doi":"10.1006/mthe.2001.0435","title":"Challenges and Strategies for Cystic Fibrosis Lung Gene Therapy","year":2001,"lang":"en","type":"review","venue":"Molecular Therapy","topic":"Neonatal Respiratory Health Research","field":"Medicine","cited_by":44,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University Medical Centre; SickKids Foundation; University of Toronto; Hospital for Sick Children; Canadian Institutes of Health Research","funders":"","keywords":"Genetic enhancement; Cystic fibrosis; Transgene; Gene delivery; Biology; Lung; Gene; Gene expression; Gene transfer; Immunology; Bioinformatics; Medicine; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004792444,0.0005862988,0.001758939,0.0003333423,0.0001082191,0.00006974174,0.0002566106,0.000482727,0.00005163553],"category_scores_gemma":[0.00004942367,0.0004353381,0.0004764942,0.0002513953,0.0001185298,0.00008916152,0.0000427827,0.0004837168,0.00001489208],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001020928,"about_ca_system_score_gemma":0.0009049346,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005171943,"about_ca_topic_score_gemma":8.12583e-7,"domain_scores_codex":[0.9972329,0.000306204,0.0005312452,0.0007809275,0.0004824054,0.0006663134],"domain_scores_gemma":[0.998212,0.0003636106,0.0001811705,0.0007783929,0.0001184301,0.0003464266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0003196976,0.00008107116,2.105356e-7,0.02126744,0.0003759114,0.0001862446,0.00006618886,1.27265e-7,0.0004014102,0.0007932254,0.00002470472,0.9764838],"study_design_scores_gemma":[0.001781469,0.001234279,0.000007421148,0.003621143,0.0001291858,0.0001668349,0.00003037638,0.000006942,0.0001525507,0.0003265071,0.9922004,0.0003428689],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001010546,0.9936357,0.0006470064,0.0002459731,0.00008773126,0.004525248,0.00003485281,0.00007803988,0.0006444547],"genre_scores_gemma":[0.00001374696,0.9964002,0.0008841919,0.0005778213,0.0002594216,0.00131716,0.00009610478,0.0002135254,0.0002377776],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9921757,"threshold_uncertainty_score":0.9998099,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1739721155908137,"score_gpt":0.451721800001982,"score_spread":0.2777496844111683,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}