{"id":"W2324536749","doi":"10.1021/jo202651t","title":"Asymmetric Total Synthesis of (+)-Virosine A via Sequential Nucleophilic Cyclizations onto an Activated Formamide","year":2012,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"Chemical synthesis and alkaloids","field":"Chemistry","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Octane; Formamide; Alkaloid; Total synthesis; Nucleophile; Mannich reaction; Piperidine; Sequence (biology); Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001475132,0.000569833,0.0003060099,0.0002620341,0.0002811575,0.0002239513,0.0003411839,0.0002611594,0.002202308],"category_scores_gemma":[0.0001300638,0.0001930314,0.0002802182,0.000209195,0.0001861959,0.0002898553,0.0003521919,0.0004615973,0.001123963],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003372183,"about_ca_system_score_gemma":0.0007194246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001045288,"about_ca_topic_score_gemma":0.002459607,"domain_scores_codex":[0.999885,0.00001280856,0.00001199409,0.0000323476,0.00002184494,0.00003600337],"domain_scores_gemma":[0.9999425,0.000006070752,0.00001118432,0.00001008438,0.00001111018,0.0000190347],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000936729,0.00002943251,0.00006728782,0.0001392381,0.00001190932,0.0002346335,0.00008002539,0.0004628624,0.9885259,0.00154407,0.0002020727,0.008608871],"study_design_scores_gemma":[0.00002542883,0.0003471979,0.0005267049,0.00001175397,0.00002005323,0.0003259944,0.00002235943,0.0007280537,0.986283,0.0002584474,0.01143337,0.00001760775],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9361049,0.003057213,0.03744682,0.0001578373,0.000189476,0.0003049683,0.001289072,0.000521349,0.02092846],"genre_scores_gemma":[0.9722095,0.001544558,0.01891461,0.00004431513,0.00002419695,0.0001240253,0.0005217351,0.00004857123,0.00656858],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002202308,"threshold_uncertainty_score":0.007367432,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01050794026049215,"score_gpt":0.226844043951015,"score_spread":0.2163361036905229,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}