{"id":"W2324734459","doi":"10.1016/j.clpt.2005.12.254","title":"PIII-46Generation of reactive oxygen species by sulfonamide reactive intermediates","year":2006,"lang":"en","type":"article","venue":"Clinical Pharmacology & Therapeutics","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Reactive oxygen species; Chemistry; Hydroxylamine; Reactive intermediate; Sulfonamide; Metabolite; Reactive nitrogen species; Pharmacology; Oxidative stress; Biochemistry; Stereochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003619906,0.0006155719,0.0002934576,0.0001781979,0.0001877176,0.0003970428,0.0002244345,0.0003836588,0.00341686],"category_scores_gemma":[0.00024779,0.0001912292,0.0003445123,0.0001680607,0.0002351116,0.0002257542,0.0001747552,0.0005473585,0.0008220636],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003045131,"about_ca_system_score_gemma":0.0002554076,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003228785,"about_ca_topic_score_gemma":0.0003249983,"domain_scores_codex":[0.9997004,0.00008322013,0.00002170138,0.00004239299,0.0000754255,0.00007682253],"domain_scores_gemma":[0.9997656,0.00004867841,0.00009070428,0.00002754932,0.00003650925,0.00003097696],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004097206,0.00007947798,0.0005324916,0.0001157142,0.00001479949,0.0001709405,0.00001779312,0.0001761125,0.9943365,0.0002140528,0.0001265268,0.00380572],"study_design_scores_gemma":[0.00003891475,0.0009446383,0.001662935,0.000006975294,0.00001939852,0.000334128,0.0000167792,0.0005851244,0.9936237,0.00008745946,0.002675704,0.000004303522],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9616252,0.009864818,0.01803648,0.0004372177,0.0001775305,0.0003014955,0.0005034839,0.0002054656,0.008848145],"genre_scores_gemma":[0.9850795,0.003490919,0.006938134,0.0001116509,0.00007069176,0.0001166144,0.0004306796,0.00001663782,0.003745228],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00341686,"threshold_uncertainty_score":0.01143056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05676418353025824,"score_gpt":0.3943139702117567,"score_spread":0.3375497866814984,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}