{"id":"W2324740323","doi":"10.1158/1538-7445.am10-4064","title":"Abstract 4064: Development of ALN-VSP: An RNAi therapeutic for solid tumors","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Arbutus Biopharma (Canada)","funders":"","keywords":"Cancer research; Small interfering RNA; Hepatocellular carcinoma; Liver tumor; Pathology; Liver cancer; Medicine; Biology; Cell culture; Transfection","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002247183,0.0004899157,0.000267191,0.0004181646,0.0001542332,0.0002576684,0.0003084363,0.0004377332,0.001521388],"category_scores_gemma":[0.00007562472,0.0001179101,0.0002522923,0.0001853933,0.0001926624,0.0002121919,0.0001734308,0.0005731537,0.0005520665],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004393382,"about_ca_system_score_gemma":0.0004636055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000841339,"about_ca_topic_score_gemma":0.001118138,"domain_scores_codex":[0.9998844,0.00001818363,0.00001056559,0.00002525549,0.0000442736,0.00001731023],"domain_scores_gemma":[0.9999521,0.00000458261,0.00001237229,0.000003253117,0.00001136171,0.0000164108],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001724681,0.0001454248,0.00007967815,0.00009778415,0.00001167942,0.00005886865,0.00001089692,0.0002720855,0.9896287,0.0002959623,0.0003459459,0.008880571],"study_design_scores_gemma":[0.0001137845,0.001575773,0.0008703598,0.000009379866,0.00002493797,0.0001966286,0.000004866183,0.001322136,0.9887893,0.00006524935,0.007022121,0.000005394882],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9410525,0.008659919,0.0327468,0.0008170131,0.0003235326,0.0007229794,0.001699868,0.0007797912,0.01319752],"genre_scores_gemma":[0.9564068,0.004624955,0.02132468,0.000197248,0.00005650128,0.0003618964,0.002291529,0.00005558649,0.01468076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001521388,"threshold_uncertainty_score":0.005089521,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09064843143201033,"score_gpt":0.4388228659782256,"score_spread":0.3481744345462152,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}