{"id":"W2325030053","doi":"10.1021/jm101403g","title":"Ethanesulfohydroxamic Acid Ester Prodrugs of Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Synthesis, Nitric oxide and Nitroxyl Release, Cyclooxygenase Inhibition, Anti-inflammatory, and Ulcerogenicity Index Studies","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Prodrug; Chemistry; Naproxen; Ibuprofen; Ulcer index; Anti-inflammatory; Pharmacology; Cyclooxygenase; Nitric oxide; Enzyme inhibitor; Enzyme; Biochemistry; Organic chemistry; Stomach","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.002211543,0.0005850657,0.001636188,0.0004066622,0.00014288,0.00001821401,0.0002043852,0.0004118025,0.00005437806],"category_scores_gemma":[0.001041466,0.0004623237,0.000274228,0.0003059149,0.0009483006,0.0003439595,0.0001239341,0.001007388,0.000004123968],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001338361,"about_ca_system_score_gemma":0.0004589187,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001402589,"about_ca_topic_score_gemma":0.000001589811,"domain_scores_codex":[0.9959534,0.0001955879,0.001712131,0.0004684023,0.001119607,0.0005508147],"domain_scores_gemma":[0.9961318,0.0003890209,0.001532487,0.0004506746,0.0007714313,0.0007246053],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002086954,0.0003251114,0.1842969,0.007087893,0.0009911648,0.002636251,0.003083513,0.000001660119,0.7977833,0.000005420496,0.0003787803,0.001323026],"study_design_scores_gemma":[0.004751015,0.0002632447,0.1090726,0.002998501,0.001102848,0.005723807,0.00273212,0.00003760632,0.8727238,0.00006383004,0.0001168563,0.0004138286],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9886581,0.01032618,0.00002105066,0.0001606873,0.0001838223,0.0004061302,0.00001325713,0.00003901469,0.0001917226],"genre_scores_gemma":[0.9951942,0.003561954,0.0002616456,0.0001545148,0.0006927343,0.00001899441,0.000004316335,0.00006711193,0.00004453852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.07522432,"threshold_uncertainty_score":0.9997829,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01303080744794622,"score_gpt":0.2389803225494262,"score_spread":0.22594951510148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}