{"id":"W2325030053","doi":"10.1021/jm101403g","title":"Ethanesulfohydroxamic Acid Ester Prodrugs of Nonsteroidal Anti-inflammatory Drugs (NSAIDs): Synthesis, Nitric oxide and Nitroxyl Release, Cyclooxygenase Inhibition, Anti-inflammatory, and Ulcerogenicity Index Studies","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":77,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Prodrug; Chemistry; Naproxen; Ibuprofen; Ulcer index; Anti-inflammatory; Pharmacology; Cyclooxygenase; Nitric oxide; Enzyme inhibitor; Enzyme; Biochemistry; Organic chemistry; Stomach","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002079535,0.000358574,0.0002321829,0.0002397737,0.0000915097,0.0001065931,0.0001621051,0.0002110943,0.0004885643],"category_scores_gemma":[0.0001398413,0.0001109298,0.000211171,0.0001462853,0.0001106905,0.0002126889,0.0001071866,0.0002064026,0.0001566893],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000150133,"about_ca_system_score_gemma":0.0001050128,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002768291,"about_ca_topic_score_gemma":0.0005319757,"domain_scores_codex":[0.9998984,0.00001941888,0.000009871963,0.00001571731,0.00003214457,0.00002438183],"domain_scores_gemma":[0.9999069,0.00001631204,0.00002825929,0.000009271675,0.00001838302,0.00002089175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001338561,0.00006889417,0.0001119226,0.00004951563,0.000005026578,0.00004401719,0.00001355149,0.0002234052,0.9961814,0.00006165253,0.00001294165,0.003093899],"study_design_scores_gemma":[0.00002499145,0.002237986,0.001380954,0.000003869509,0.00001611538,0.0001384556,0.000009146214,0.0003155555,0.994568,0.00001757211,0.0012843,0.000002988865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9889479,0.004976999,0.003949014,0.00002802473,0.00001802586,0.0001024656,0.0001882081,0.00002580476,0.001763621],"genre_scores_gemma":[0.9887584,0.003429777,0.00478387,0.00002758227,0.00002201997,0.00005898072,0.0003251488,0.00001075061,0.002583314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004885643,"threshold_uncertainty_score":0.001634359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01303080744794622,"score_gpt":0.2389803225494262,"score_spread":0.22594951510148,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}