{"id":"W2325129919","doi":"10.1021/nn404473g","title":"Caspase-1 Activity in Microglia Stimulated by Pro-Inflammagen Nanocrystals","year":2013,"lang":"en","type":"article","venue":"ACS Nano","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Université du Québec à Montréal","funders":"Canadian Institutes of Health Research","keywords":"Microglia; Lipopolysaccharide; Inflammation; Cell biology; Caspase 1; Caspase 3; In vivo; Chemistry; Inflammasome; Apoptosis; Biochemistry; Programmed cell death; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007451383,0.0001866761,0.0001683503,0.00003924251,0.00004544586,0.00003565462,0.0001855897,0.0002225542,0.0001205763],"category_scores_gemma":[0.00003108005,0.0001631259,0.00005608886,0.0001098948,0.00004969825,0.00001185767,0.00009432536,0.00009862618,0.00006089424],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000180452,"about_ca_system_score_gemma":0.00005708072,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003189746,"about_ca_topic_score_gemma":0.00006386475,"domain_scores_codex":[0.9989862,0.00005252859,0.0001740509,0.0003559652,0.0001009119,0.0003303085],"domain_scores_gemma":[0.9994301,0.000007278111,0.00006393503,0.0003523656,0.00006428351,0.00008208884],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002995298,0.00005691845,0.003410865,0.00001306495,0.00001560163,0.00000575467,0.00002392725,0.000002917174,0.9859142,9.991008e-7,0.006562142,0.003963598],"study_design_scores_gemma":[0.0006480851,0.000102966,0.005681532,0.000007413207,0.00001282196,0.00001044391,0.00001105667,0.000004229587,0.9795322,0.000008233943,0.01376726,0.000213762],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986336,0.0001133286,0.00001199346,0.0001501953,0.0001368047,0.0004701808,0.00003541184,0.00001866348,0.00042986],"genre_scores_gemma":[0.9956129,0.00003021775,0.000107137,0.000175874,0.0001136465,0.00005896994,0.0001315798,0.00002583596,0.003743893],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007205118,"threshold_uncertainty_score":0.665208,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007117109624185907,"score_gpt":0.2361584546162652,"score_spread":0.2290413449920793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}