{"id":"W2325129919","doi":"10.1021/nn404473g","title":"Caspase-1 Activity in Microglia Stimulated by Pro-Inflammagen Nanocrystals","year":2013,"lang":"en","type":"article","venue":"ACS Nano","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Université de Montréal; Université du Québec à Montréal","funders":"Canadian Institutes of Health Research","keywords":"Microglia; Lipopolysaccharide; Inflammation; Cell biology; Caspase 1; Caspase 3; In vivo; Chemistry; Inflammasome; Apoptosis; Biochemistry; Programmed cell death; Biology; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002321275,0.0002313198,0.0001596619,0.000131425,0.0001120412,0.0001769345,0.0001308047,0.0002857034,0.0006983817],"category_scores_gemma":[0.0001887978,0.0001061042,0.0001736875,0.0001042915,0.0001558726,0.0002429538,0.0001096268,0.0003381264,0.0001480506],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002441797,"about_ca_system_score_gemma":0.0001274259,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004514306,"about_ca_topic_score_gemma":0.0003798089,"domain_scores_codex":[0.9998523,0.00002612502,0.00001299075,0.00003525094,0.00004097828,0.00003233158],"domain_scores_gemma":[0.9999064,0.00002189874,0.00002333803,0.000009574163,0.00002629872,0.00001237131],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005009833,0.000006719794,0.00004972031,0.00001324012,0.000001261511,0.00001588367,0.00001065343,0.00002032997,0.9995489,0.00003285306,0.000007475875,0.0002429048],"study_design_scores_gemma":[0.000006397031,0.00006552772,0.0005616714,0.000002021125,0.000002679559,0.00005119678,0.00001053262,0.0004338578,0.9986547,0.00002931286,0.0001801879,0.000001839461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950585,0.0007390962,0.003246272,0.00006477933,0.00001844558,0.0000144324,0.000129625,0.00002207022,0.0007066374],"genre_scores_gemma":[0.9939856,0.0004764977,0.004157487,0.00003846515,0.000008880028,0.0000392366,0.0001838203,0.000009275903,0.001100785],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006983817,"threshold_uncertainty_score":0.002336323,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007117109624185907,"score_gpt":0.2361584546162652,"score_spread":0.2290413449920793,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}