{"id":"W2325147559","doi":"10.1038/sj.gt.3301355","title":"HVJ-liposome-mediated transfection of HSVtk gene driven by AFP promoter inhibits hepatic tumor growth of hepatocellular carcinoma in SCID mice","year":2001,"lang":"en","type":"article","venue":"Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Japan Society for the Promotion of Science","keywords":"Suicide gene; Genetic enhancement; Transfection; Biology; Cancer research; Thymidine kinase; Viral vector; Hepatocellular carcinoma; Molecular biology; Virology; Gene; Virus","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004480396,0.0002914728,0.0004037275,0.0002161332,0.00004735846,0.00001047045,0.000350884,0.0001907398,0.00008454773],"category_scores_gemma":[0.00002297352,0.000284711,0.0001630071,0.0005233256,0.0001661408,0.00001034383,0.00004077503,0.0001625164,0.00001105096],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004519532,"about_ca_system_score_gemma":0.0001771675,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002721748,"about_ca_topic_score_gemma":0.00019125,"domain_scores_codex":[0.9978007,0.0003145352,0.0005377411,0.0005160409,0.0003617721,0.0004691786],"domain_scores_gemma":[0.9990239,0.00002019847,0.0001558175,0.0004657925,0.0002156874,0.0001186707],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002981992,0.0004107982,0.06758738,0.00004413019,0.00009381052,0.00001354957,0.0002216995,0.00003882308,0.9276108,6.841138e-7,0.00005005914,0.0009462804],"study_design_scores_gemma":[0.00316387,0.004214791,0.004169812,0.00002178058,0.00001098822,0.0000229802,0.00001693338,0.000495817,0.9874325,0.00003537814,0.0001484494,0.000266637],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9943889,0.004224265,0.0002077315,0.0001253391,0.00006058662,0.0008602639,0.0000847243,0.00001578522,0.00003244191],"genre_scores_gemma":[0.9961128,0.002919639,0.000136181,0.0001497943,0.00009813944,0.00008362364,0.0003703173,0.00007036754,0.00005920011],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06341757,"threshold_uncertainty_score":0.9999605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01269021800539375,"score_gpt":0.2442323010178092,"score_spread":0.2315420830124154,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}