{"id":"W2325217990","doi":"10.1139/bcb-2012-0080","title":"Mechanism of cardiomyocyte PGC-1α gene regulation by ERRα","year":2012,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital","funders":"Canadian Institutes of Health Research","keywords":"Coactivator; Chromatin immunoprecipitation; Gene knockdown; Biology; Nuclear receptor; Regulation of gene expression; Cell biology; Gene expression; Mitochondrial biogenesis; Histone deacetylase; Peroxisome proliferator-activated receptor; Transcription factor; Histone; Gene; Mitochondrion; Promoter; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001056437,0.00009103898,0.0002122322,0.00001510415,0.00002422031,0.000001111252,0.00003106928,0.0002024257,0.0000946126],"category_scores_gemma":[0.00001316244,0.00007725666,0.0000432816,0.00003964073,0.00007084812,0.00001689401,0.00002641397,0.00006013799,0.000007256587],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007335544,"about_ca_system_score_gemma":0.00001861301,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001129885,"about_ca_topic_score_gemma":3.11553e-8,"domain_scores_codex":[0.9994958,0.00001682558,0.0001345056,0.0001370676,0.00004181226,0.0001739631],"domain_scores_gemma":[0.9996194,0.00001186449,0.00006443799,0.0001622345,0.00002915196,0.0001129087],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003772186,0.00004388258,0.000627217,0.00006201022,0.00002865252,5.937914e-7,0.00004565227,1.904566e-8,0.9953528,0.0003887101,0.0008094864,0.002603226],"study_design_scores_gemma":[0.0004676422,0.00004758824,0.0005185044,0.000005904701,0.00009976308,0.00003372244,0.0000290543,0.000002927292,0.9430587,0.0001059145,0.055558,0.00007231114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9723586,0.01937676,0.0003156138,0.00006799655,0.0001287153,0.00007906167,0.00002552842,0.00001549766,0.007632171],"genre_scores_gemma":[0.9945158,0.0004672938,0.0004470714,0.00008288262,0.0003230961,0.000004704058,0.0001829168,0.000007086179,0.003969177],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05474851,"threshold_uncertainty_score":0.3150435,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0103094456846354,"score_gpt":0.2395597719226076,"score_spread":0.2292503262379721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}