{"id":"W2325217990","doi":"10.1139/bcb-2012-0080","title":"Mechanism of cardiomyocyte PGC-1α gene regulation by ERRα","year":2012,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Adipose Tissue and Metabolism","field":"Medicine","cited_by":31,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Boniface Hospital","funders":"Canadian Institutes of Health Research","keywords":"Coactivator; Chromatin immunoprecipitation; Gene knockdown; Biology; Nuclear receptor; Regulation of gene expression; Cell biology; Gene expression; Mitochondrial biogenesis; Histone deacetylase; Peroxisome proliferator-activated receptor; Transcription factor; Histone; Gene; Mitochondrion; Promoter; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001832923,0.0003400429,0.0002405142,0.0001748347,0.0001297878,0.0001959516,0.0002940455,0.0002252307,0.0008470515],"category_scores_gemma":[0.0000828871,0.0001335885,0.0002745732,0.00006763326,0.0002898545,0.0001659875,0.0001930533,0.0004205093,0.0003972095],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002663778,"about_ca_system_score_gemma":0.000156256,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002823063,"about_ca_topic_score_gemma":0.0003398572,"domain_scores_codex":[0.9998679,0.00002256816,0.000008821577,0.00004371387,0.00003203633,0.00002486599],"domain_scores_gemma":[0.9999098,0.00001069621,0.00003314162,0.00001377165,0.0000146246,0.00001800521],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001721092,0.00002641971,0.0004764354,0.0001229338,0.00001299508,0.000220486,0.00002441262,0.0001053839,0.9949561,0.0006413038,0.0001674661,0.003073911],"study_design_scores_gemma":[0.00007368319,0.0004463538,0.02939866,0.0000437389,0.0000454617,0.0009792519,0.00009404768,0.001354159,0.9562891,0.0004667802,0.01079239,0.00001634885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9025365,0.03621182,0.0491931,0.001523955,0.0004884086,0.0001554632,0.001266429,0.0004589782,0.008165332],"genre_scores_gemma":[0.9779664,0.008426693,0.005849496,0.0003392492,0.00009273213,0.00008698626,0.0005781341,0.00003574167,0.006624701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008470515,"threshold_uncertainty_score":0.002833664,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0103094456846354,"score_gpt":0.2395597719226076,"score_spread":0.2292503262379721,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}