{"id":"W2325292714","doi":"10.1021/sb3000468","title":"Programming Membrane Fusion and Subsequent Apoptosis into Mammalian Cells","year":2012,"lang":"en","type":"letter","venue":"ACS Synthetic Biology","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Syncytium; Cell fusion; Cell biology; Vesicular stomatitis virus; Biology; Apoptosis; Fusion mechanism; Oncolytic virus; Cell; Multinucleate; Lipid bilayer fusion; Cell culture; Immune system; Virology; Virus; Biochemistry; Immunology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.000584283,0.0005504055,0.0005170032,0.0001777037,0.0001727402,0.00004726699,0.000593089,0.002082086,0.0001727077],"category_scores_gemma":[0.00005714582,0.0004828128,0.0001690413,0.0001126018,0.0006146533,0.000003825357,0.0004812202,0.0009293966,0.0001024316],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005029796,"about_ca_system_score_gemma":0.0001152009,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001469594,"about_ca_topic_score_gemma":0.00007237727,"domain_scores_codex":[0.996757,0.0005634706,0.0004003161,0.0009992308,0.0002110392,0.001068962],"domain_scores_gemma":[0.9984766,0.00006964088,0.0001922539,0.0009792488,0.0001079039,0.0001743641],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002423832,0.00004672515,0.00007667937,0.0001720802,0.0001449706,0.00001014103,0.00005793693,4.031071e-7,0.924844,0.00000697424,0.02880555,0.0455921],"study_design_scores_gemma":[0.0002031258,0.0009851137,0.00000307731,0.00002062162,0.00004465435,0.00002646834,0.00001072228,8.393384e-7,0.4994862,0.00004820198,0.4988416,0.0003293786],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8170996,0.0112474,0.0001497548,0.168117,0.001271153,0.001470929,0.0001254771,0.000078596,0.0004401164],"genre_scores_gemma":[0.7928205,0.006412716,0.002388721,0.1812696,0.00833244,0.0006786693,0.003883316,0.000454407,0.00375959],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4700361,"threshold_uncertainty_score":0.9997624,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01783259343634467,"score_gpt":0.277153326782074,"score_spread":0.2593207333457294,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}