{"id":"W2325322851","doi":"10.1021/ol102795g","title":"Applications of Organocatalytic Asymmetric Synthesis to Drug Prototypes—Dual Action and Selective Inhibitors of <i>n</i>-Nitric Oxide Synthase with Activity Against the 5-HT<sub>1D/1B</sub> Subreceptors","year":2011,"lang":"en","type":"article","venue":"Organic Letters","topic":"Asymmetric Synthesis and Catalysis","field":"Chemistry","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; NeurAxon (Canada)","funders":"","keywords":"Chemistry; Conjugate; Aniline; Combinatorial chemistry; Enantioselective synthesis; Furan; Catalysis; Stereochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000354578,0.0005337439,0.0003315807,0.0002451925,0.0002210856,0.0004497251,0.0005833126,0.0003784758,0.001277206],"category_scores_gemma":[0.0003621002,0.0002078557,0.0003125866,0.0002425934,0.0004284475,0.0004451798,0.0004020044,0.0008739204,0.0004528405],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005649358,"about_ca_system_score_gemma":0.0004881016,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005837373,"about_ca_topic_score_gemma":0.0008903153,"domain_scores_codex":[0.9997664,0.00004824798,0.00002260428,0.00005328568,0.00005568232,0.00005374214],"domain_scores_gemma":[0.9998717,0.00002740549,0.00004588117,0.00001880617,0.00002168586,0.0000144223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002754203,0.0001003165,0.0001202575,0.0002209098,0.00002583403,0.0004181199,0.0001379809,0.001433235,0.9708319,0.007632329,0.0005428665,0.01826089],"study_design_scores_gemma":[0.00004821439,0.0004787327,0.0001282411,0.000007805243,0.00001682807,0.0003043116,0.00001921393,0.0009078199,0.9890688,0.0003919516,0.008612306,0.00001581102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8493707,0.008139957,0.09963699,0.0007925748,0.0004628726,0.0006003369,0.0006006118,0.0004952914,0.03990071],"genre_scores_gemma":[0.9665977,0.003492553,0.02473698,0.0001335021,0.00005736992,0.0001586895,0.0002537617,0.00004323914,0.004526076],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001277206,"threshold_uncertainty_score":0.004272699,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008012789517365558,"score_gpt":0.1926909884779259,"score_spread":0.1846781989605604,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}