{"id":"W2325344425","doi":"10.1021/cb400775z","title":"Antiviral Activity of an Isatin Derivative via Induction of PERK-Nrf2-Mediated Suppression of Cap-Independent Translation","year":2014,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Unfolded protein response; Endoplasmic reticulum; GCLM; Small interfering RNA; Cell biology; eIF2; Ubiquitin ligase; Biology; Viral replication; Molecular biology; Chemistry; GCLC; Protein subunit; Biochemistry; Ubiquitin; Ribosome; RNA; Virus; Gene; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008838557,0.0002678792,0.0002085983,0.0001759918,0.00008627648,0.0001419991,0.0001056691,0.0001510634,0.0005885575],"category_scores_gemma":[0.00004326046,0.00006524806,0.0002525077,0.00009896325,0.00008119364,0.0001167304,0.0001086182,0.0002809182,0.0001640539],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001303485,"about_ca_system_score_gemma":0.00008613394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001493226,"about_ca_topic_score_gemma":0.0002741165,"domain_scores_codex":[0.9999651,0.000006152757,0.00000398561,0.000007246886,0.000008070851,0.000009492905],"domain_scores_gemma":[0.999972,0.000002965906,0.000009496275,0.00000327864,0.000005282687,0.000006929043],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007710066,0.00002846985,0.00007747405,0.00006557466,0.000007724649,0.00004631176,0.00001039449,0.0001263486,0.9975476,0.00005604118,0.00003129581,0.001925745],"study_design_scores_gemma":[0.00003016042,0.0009065841,0.001622129,0.000006797128,0.00002481503,0.0001866047,0.00001128234,0.0005611946,0.992753,0.00003272974,0.003859026,0.000005643266],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891803,0.004388661,0.003154103,0.00008325229,0.00004191609,0.00005703268,0.0003591979,0.00008395832,0.002651635],"genre_scores_gemma":[0.9936818,0.001509123,0.002756666,0.00006692253,0.00001194402,0.00002363273,0.0006846948,0.00001267604,0.001252552],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005885575,"threshold_uncertainty_score":0.00196892,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009795141863960435,"score_gpt":0.2585645023780778,"score_spread":0.2487693605141173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}