{"id":"W2325344425","doi":"10.1021/cb400775z","title":"Antiviral Activity of an Isatin Derivative via Induction of PERK-Nrf2-Mediated Suppression of Cap-Independent Translation","year":2014,"lang":"en","type":"article","venue":"ACS Chemical Biology","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":37,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Paul's Hospital; University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Unfolded protein response; Endoplasmic reticulum; GCLM; Small interfering RNA; Cell biology; eIF2; Ubiquitin ligase; Biology; Viral replication; Molecular biology; Chemistry; GCLC; Protein subunit; Biochemistry; Ubiquitin; Ribosome; RNA; Virus; Gene; Virology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116269,0.0001207473,0.0002522653,0.00003478132,0.00001457413,0.000001317987,0.0001226054,0.0002857636,0.00001263884],"category_scores_gemma":[0.0001895602,0.0001023245,0.00007517181,0.00006273681,0.0002424916,0.000007662707,0.00004922376,0.00008276121,5.049391e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005412158,"about_ca_system_score_gemma":0.00003020386,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008061923,"about_ca_topic_score_gemma":0.00000689308,"domain_scores_codex":[0.9990837,0.0001554027,0.0002720416,0.0002629223,0.00008793327,0.0001380263],"domain_scores_gemma":[0.9993213,0.0000536454,0.0002403615,0.0002272698,0.0001018223,0.00005553324],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004027976,0.0002058804,0.006411543,0.00004192805,0.00002919145,1.410634e-7,0.00006419975,0.000005949712,0.9816532,0.0000337509,0.00001044487,0.01114098],"study_design_scores_gemma":[0.0008300265,0.0004222166,0.005763762,0.00001329399,0.00002247644,0.000001678179,0.0000287339,0.0003081808,0.9922699,0.0001878329,0.00005298995,0.00009889606],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981182,0.00006364741,0.001347434,0.00003168449,0.00005766858,0.0001114357,0.0000792327,0.000005009876,0.0001856662],"genre_scores_gemma":[0.998932,0.00003067279,0.0004024224,0.00001408,0.00005302885,0.000006816872,0.0005493823,0.000008723343,0.000002885073],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01104208,"threshold_uncertainty_score":0.4172671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009795141863960435,"score_gpt":0.2585645023780778,"score_spread":0.2487693605141173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}