{"id":"W2325356426","doi":"10.1097/mib.0000000000000398","title":"Properdin Regulation of Complement Activation Affects Colitis in Interleukin 10 Gene–Deficient Mice","year":2015,"lang":"en","type":"article","venue":"Inflammatory Bowel Diseases","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"Dalhousie University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Crohn's and Colitis Foundation; IWK Health Centre; Cardiff University; Nova Scotia Health Research Foundation; Crohn's and Colitis Foundation of Canada","keywords":"Properdin; Immunology; Complement system; Colitis; Alternative complement pathway; Complement (music); Acquired immune system; Innate immune system; Biology; Complement factor B; Immune system; Regulator; Gene; Genetics; Phenotype","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002923487,0.001020112,0.000551997,0.0008822142,0.0002494182,0.0004364896,0.0004354676,0.000841359,0.002812578],"category_scores_gemma":[0.0002623421,0.000427994,0.0004604027,0.0003249066,0.000766912,0.0004343708,0.0003582335,0.001180677,0.0006628932],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006512608,"about_ca_system_score_gemma":0.000361208,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005077685,"about_ca_topic_score_gemma":0.0009677873,"domain_scores_codex":[0.9996151,0.00006760237,0.00006212772,0.00009779695,0.00006324823,0.00009413026],"domain_scores_gemma":[0.9991056,0.00008775658,0.0003919879,0.00006138755,0.0000406451,0.0003126205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006873627,0.0001418458,0.0002774882,0.00005330624,0.000008106792,0.0001267995,0.00001438168,0.00005763851,0.9979408,0.00007154365,0.00003790365,0.0005828194],"study_design_scores_gemma":[0.0005048307,0.002841967,0.01554847,0.0000589128,0.0001052072,0.001881892,0.00009002983,0.001507161,0.9750334,0.0001430344,0.00226262,0.00002246695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955936,0.0008769167,0.001397447,0.0001677121,0.00004068802,0.00006574348,0.0007413999,0.0001504362,0.000966051],"genre_scores_gemma":[0.9904345,0.0009683153,0.004344577,0.0001689648,0.00002830118,0.0001278587,0.0008988646,0.00009659475,0.002932027],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002812578,"threshold_uncertainty_score":0.009408951,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02441772233288659,"score_gpt":0.2571036827934893,"score_spread":0.2326859604606027,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}