{"id":"W2325372415","doi":"10.1124/dmd.116.069468","title":"Cysteinyl Leukotriene Receptor 1/2 Antagonists Nonselectively Modulate Organic Anion Transport by Multidrug Resistance Proteins (MRP1-4)","year":2016,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Multidrug resistance-associated protein 2; ABCC1; Chemistry; Efflux; Leukotriene C4; Stereochemistry; Antagonist; Leukotriene D4; Leukotriene; P-glycoprotein; Transporter; ATP-binding cassette transporter; Receptor; Biochemistry; Biology; Multiple drug resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001672076,0.000274229,0.0004077328,0.000266534,0.0002048926,0.0005826509,0.0002335864,0.0003235188,0.002435508],"category_scores_gemma":[0.0004375571,0.0002028537,0.0003226582,0.0001659532,0.0002057071,0.0003473095,0.0001915233,0.0006331819,0.0005732065],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003509377,"about_ca_system_score_gemma":0.0002395338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005466468,"about_ca_topic_score_gemma":0.001398766,"domain_scores_codex":[0.999793,0.00006845933,0.00001921827,0.00001975521,0.00003264248,0.00006694812],"domain_scores_gemma":[0.9998714,0.0000330519,0.00004461801,0.00001766007,0.00001722236,0.0000161989],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001244225,0.0001303568,0.0006324605,0.00005132057,0.00004992448,0.0001536353,0.00004000061,0.00009820532,0.9876568,0.0003924835,0.0004593637,0.009091157],"study_design_scores_gemma":[0.0004447367,0.003461103,0.01299669,0.00001464544,0.0001865762,0.0009913306,0.0001210118,0.001348224,0.9698092,0.000383606,0.0102207,0.0000222143],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9929236,0.002922823,0.001359704,0.0002943189,0.00005958754,0.00003546967,0.0001389059,0.0001063462,0.002159225],"genre_scores_gemma":[0.9947845,0.001441851,0.0008056228,0.0001874225,0.00003601994,0.00002394862,0.0002423345,0.00002758452,0.002450587],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002435508,"threshold_uncertainty_score":0.008147597,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003939199543635516,"score_gpt":0.2029496804808829,"score_spread":0.1990104809372474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}