{"id":"W2325372415","doi":"10.1124/dmd.116.069468","title":"Cysteinyl Leukotriene Receptor 1/2 Antagonists Nonselectively Modulate Organic Anion Transport by Multidrug Resistance Proteins (MRP1-4)","year":2016,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"Drug Transport and Resistance Mechanisms","field":"Medicine","cited_by":27,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"Canadian Institutes of Health Research","keywords":"Multidrug resistance-associated protein 2; ABCC1; Chemistry; Efflux; Leukotriene C4; Stereochemistry; Antagonist; Leukotriene D4; Leukotriene; P-glycoprotein; Transporter; ATP-binding cassette transporter; Receptor; Biochemistry; Biology; Multiple drug resistance","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003421158,0.0004044784,0.0005873211,0.0001475167,0.0003090753,0.00002916411,0.0001162058,0.0001796914,0.0001127995],"category_scores_gemma":[0.00001846139,0.000279619,0.0001551455,0.0003487423,0.0001623251,0.0004260789,0.00001297178,0.0001810106,0.00003874782],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009219864,"about_ca_system_score_gemma":0.0001070582,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005613157,"about_ca_topic_score_gemma":0.000108285,"domain_scores_codex":[0.9977335,0.00008620927,0.0005006599,0.0007356901,0.00043088,0.0005130629],"domain_scores_gemma":[0.998907,0.00003142112,0.0001744756,0.0003627091,0.0001804884,0.0003438912],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00147544,0.0002818033,0.0007556669,0.0001766131,0.00007057464,0.00002825091,0.0006748918,2.103748e-7,0.9907371,0.001476338,0.0007913151,0.003531843],"study_design_scores_gemma":[0.007589373,0.000121492,0.08637197,0.0008185311,0.0004389021,0.0000368306,0.0001964026,0.00001670836,0.85772,0.0007145113,0.04522567,0.0007495769],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9723886,0.003152458,0.01896652,0.002691258,0.000355752,0.001165855,0.0004890442,0.0002313888,0.0005591059],"genre_scores_gemma":[0.986483,0.001483318,0.001897596,0.0002303724,0.0002010442,0.0001087271,0.0003929895,0.00007659887,0.009126347],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.133017,"threshold_uncertainty_score":0.9999656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003939199543635516,"score_gpt":0.2029496804808829,"score_spread":0.1990104809372474,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}