{"id":"W2325391880","doi":"10.1021/jm500802j","title":"Discovery of Small-Molecule Inhibitors Selectively Targeting the DNA-Binding Domain of the Human Androgen Receptor","year":2014,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":119,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Prostate Cancer Canada; U.S. Department of Defense","keywords":"Enzalutamide; Androgen receptor; Chemistry; Virtual screening; Prostate cancer; Small molecule; Mutagenesis; Computational biology; Drug discovery; Cancer research; Biochemistry; Cancer; Mutation; Biology; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001828613,0.0004475694,0.0004859373,0.0002772665,0.0001226476,0.000338601,0.0003708146,0.0002040893,0.00102163],"category_scores_gemma":[0.0001400469,0.000164317,0.0002676953,0.0002216154,0.000168339,0.0001699481,0.0002162964,0.0005615167,0.0003146713],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002768929,"about_ca_system_score_gemma":0.0003089475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005145727,"about_ca_topic_score_gemma":0.002172341,"domain_scores_codex":[0.9999336,0.00001164345,0.00000461867,0.00001391803,0.00001970793,0.00001649315],"domain_scores_gemma":[0.9999679,0.000006260273,0.000008356297,0.000002525282,0.000005060966,0.000009941214],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007218528,0.0006655384,0.00088598,0.0004738032,0.0001159274,0.0005272376,0.00006306529,0.006235524,0.9310249,0.001547679,0.001047566,0.05669085],"study_design_scores_gemma":[0.001157952,0.009297796,0.003697261,0.00008016683,0.0002978965,0.001406236,0.00006838688,0.01484701,0.936913,0.0004123847,0.03175536,0.00006653953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9567204,0.01808071,0.01599419,0.0004057426,0.0001652865,0.0005877357,0.001107224,0.0003765259,0.006562248],"genre_scores_gemma":[0.9746251,0.00934527,0.01069809,0.0002389525,0.00002512814,0.0001315057,0.001291033,0.00001975762,0.003625153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00102163,"threshold_uncertainty_score":0.003417671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.013563947773341,"score_gpt":0.2781430089635776,"score_spread":0.2645790611902366,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}