{"id":"W2325452267","doi":"10.1002/1873-3468.12110","title":"Structural basis for a novel interaction between <scp>TXNIP</scp> and Vav2","year":2016,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Natural Science Foundation of China; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Genome Canada; Ontario Genomics Institute; Central China Normal University; AbbVie; Canadian Institutes of Health Research; Wellcome; GlaxoSmithKline; Takeda Pharmaceuticals U.S.A.; Pfizer; Boehringer Ingelheim","keywords":"TXNIP; Phosphorylation; Ubiquitin ligase; Cell biology; Ubiquitin; Thioredoxin-Interacting Protein; Immunoprecipitation; Biology; Tyrosine phosphorylation; Chemistry; Biochemistry; Thioredoxin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006654699,0.0001214231,0.0001098034,0.00003031056,0.00008069097,0.00001377273,0.00009441903,0.0001149397,0.000005062326],"category_scores_gemma":[0.0001677122,0.00008307581,0.00006037859,0.00002347517,0.0001192889,0.000008217225,0.00005527281,0.00004561179,0.0000035605],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001021419,"about_ca_system_score_gemma":0.000008480924,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007519642,"about_ca_topic_score_gemma":0.00000780875,"domain_scores_codex":[0.9993397,0.00002714865,0.0001135755,0.0002851051,0.00003825027,0.0001962483],"domain_scores_gemma":[0.9996072,0.0001066251,0.00006716955,0.0001400461,0.00002977878,0.00004918442],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002313487,0.000003666837,0.0374999,0.000007725122,0.00007530086,3.732439e-7,0.0000296997,8.222637e-7,0.9538088,0.00002612394,0.004235423,0.004289002],"study_design_scores_gemma":[0.001013133,0.0002303441,0.1617886,0.00002820905,0.0000343755,0.00001262601,0.00006595394,0.000006088929,0.7781325,0.00005869363,0.05852019,0.0001093051],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9865381,0.0000630774,0.01131316,0.001535212,0.000192459,0.0001413257,0.0001174102,0.000009641744,0.00008965049],"genre_scores_gemma":[0.9973096,0.00002344837,0.0007469294,0.001039171,0.0004775845,0.0000232634,0.00009191992,0.00001233576,0.0002757089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1756763,"threshold_uncertainty_score":0.3387733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01715736119177797,"score_gpt":0.2654001877522937,"score_spread":0.2482428265605157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}