{"id":"W2325452267","doi":"10.1002/1873-3468.12110","title":"Structural basis for a novel interaction between <scp>TXNIP</scp> and Vav2","year":2016,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Redox biology and oxidative stress","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"National Natural Science Foundation of China; Ontario Ministry of Economic Development and Innovation; Wellcome Trust; Genome Canada; Ontario Genomics Institute; Central China Normal University; AbbVie; Canadian Institutes of Health Research; Wellcome; GlaxoSmithKline; Takeda Pharmaceuticals U.S.A.; Pfizer; Boehringer Ingelheim","keywords":"TXNIP; Phosphorylation; Ubiquitin ligase; Cell biology; Ubiquitin; Thioredoxin-Interacting Protein; Immunoprecipitation; Biology; Tyrosine phosphorylation; Chemistry; Biochemistry; Thioredoxin; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008635369,0.000389006,0.0003108208,0.0001348484,0.0005625992,0.0004103415,0.0006188449,0.0005785823,0.001997055],"category_scores_gemma":[0.0001781904,0.0001996769,0.0003211967,0.000132851,0.0003315229,0.0002469902,0.0003680036,0.0006497165,0.0005152618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000582242,"about_ca_system_score_gemma":0.0003083404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001409062,"about_ca_topic_score_gemma":0.001502602,"domain_scores_codex":[0.9998913,0.00001483168,0.000006102296,0.00002667092,0.00003456009,0.00002654962],"domain_scores_gemma":[0.9998837,0.00001932795,0.00002931653,0.00000731821,0.00001314507,0.00004726828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005012227,0.0001502775,0.001415453,0.000114146,0.00006996769,0.002374873,0.00009350665,0.001592773,0.988677,0.002290359,0.0007361976,0.001984178],"study_design_scores_gemma":[0.0003159453,0.0005392989,0.03958301,0.00004210888,0.0001332321,0.004418191,0.0003642094,0.04259996,0.8931507,0.002256879,0.01651668,0.00007985149],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937697,0.0006623358,0.00275989,0.0002511159,0.00006919841,0.00002077753,0.0001615519,0.0001150684,0.0021904],"genre_scores_gemma":[0.9978471,0.0001121003,0.0007870935,0.00009135702,0.00001459735,0.000009154849,0.0002669516,0.00001035655,0.0008613594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001997055,"threshold_uncertainty_score":0.006680787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01715736119177797,"score_gpt":0.2654001877522937,"score_spread":0.2482428265605157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}