{"id":"W2325458900","doi":"10.1021/acs.biochem.5b01131","title":"Multiple Src Homology 3 Binding to the Ubiquitin Ligase Itch Conserved Proline-Rich Region","year":2015,"lang":"en","type":"article","venue":"Biochemistry","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Natural Sciences and Engineering Research Council of Canada; Fonds de recherche du Québec – Nature et technologies; Canadian Institutes of Health Research","keywords":"SH3 domain; Isothermal titration calorimetry; Ubiquitin; Endocytic cycle; Biochemistry; Homotetramer; Ubiquitin-Protein Ligases; Biology; Cyclic nucleotide-binding domain; Plasma protein binding; Binding site; Ubiquitin ligase; Chemistry; Cell biology; Proto-oncogene tyrosine-protein kinase Src; Peptide sequence; Signal transduction; Receptor; Endocytosis; Gene; Protein subunit","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001283598,0.000320323,0.000265069,0.0001483183,0.0001894748,0.0002313659,0.000204115,0.0002216599,0.001662488],"category_scores_gemma":[0.0001501166,0.0001092797,0.0003858393,0.0001583714,0.000113562,0.0001315334,0.0002450123,0.0003445433,0.0005324127],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004324946,"about_ca_system_score_gemma":0.0001546639,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001019783,"about_ca_topic_score_gemma":0.001620017,"domain_scores_codex":[0.9997421,0.00004112209,0.00001032534,0.00005444181,0.00008283671,0.00006915664],"domain_scores_gemma":[0.9999218,0.00001438467,0.00001453232,0.000009606276,0.00001618347,0.00002346658],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008864027,0.00001823716,0.0005880761,0.00003273928,0.00001798706,0.00005829631,0.0000102283,0.0001206414,0.998061,0.00006151302,0.00006901159,0.0008736441],"study_design_scores_gemma":[0.000009819089,0.000109381,0.0134808,0.000004699404,0.00001623789,0.0003492454,0.00002228112,0.002971118,0.9812394,0.00002949436,0.001760907,0.000006580693],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959651,0.00070912,0.002292296,0.00003889301,0.00001254556,0.00001083941,0.0001982693,0.00004370094,0.0007291289],"genre_scores_gemma":[0.9954885,0.0002322369,0.001433775,0.00006858419,0.000004799782,0.00001174774,0.0005664405,0.00001522397,0.002178779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001662488,"threshold_uncertainty_score":0.00556159,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03873566956691511,"score_gpt":0.262716068065975,"score_spread":0.2239803984990599,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}