{"id":"W2325514476","doi":"10.1111/febs.13671","title":"Single substitutions to closely related amino acids contribute to the functional diversification of an insect‐inducible, positively selected plant cystatin","year":2016,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Cystatin; Biology; Protease; Proteases; Biochemistry; Amino acid; Cysteine; Leucine; Colorado potato beetle; Cysteine protease; Cystatin C; Enzyme; Botany; PEST analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001723415,0.0002777546,0.0002465058,0.00014711,0.0001027419,0.0002913401,0.0001690274,0.0002310332,0.0007346954],"category_scores_gemma":[0.0001746262,0.0001198163,0.0002468407,0.0001254656,0.0001972061,0.0001137842,0.000252677,0.0003843025,0.0002021258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001442593,"about_ca_system_score_gemma":0.0001231475,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002540166,"about_ca_topic_score_gemma":0.0005386432,"domain_scores_codex":[0.9998503,0.00003320259,0.00001665727,0.00002777823,0.00004505298,0.00002702765],"domain_scores_gemma":[0.9997917,0.00004859109,0.00006639361,0.00002487119,0.00002169045,0.00004684614],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006386513,0.00001000886,0.0008996826,0.00001387057,0.00001079417,0.00008709571,0.000007658172,0.00005231649,0.9981766,0.0000140995,0.000005454519,0.000658482],"study_design_scores_gemma":[0.0000164439,0.0004760554,0.05932042,0.000008442716,0.00008224266,0.001557524,0.00006027224,0.002100663,0.9351553,0.00004992257,0.001160636,0.00001197584],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9989257,0.000164527,0.0006017777,0.0000106308,0.000003414415,0.000006055147,0.00003585526,0.00001082309,0.0002410159],"genre_scores_gemma":[0.9991154,0.00006195855,0.0005326582,0.00001779145,0.0000015633,0.000003742495,0.00007108312,0.000008104963,0.0001877012],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007346954,"threshold_uncertainty_score":0.002457798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01800352547211238,"score_gpt":0.2279680461777239,"score_spread":0.2099645207056115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}