{"id":"W2325514476","doi":"10.1111/febs.13671","title":"Single substitutions to closely related amino acids contribute to the functional diversification of an insect‐inducible, positively selected plant cystatin","year":2016,"lang":"en","type":"article","venue":"FEBS Journal","topic":"Insect Resistance and Genetics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Cystatin; Biology; Protease; Proteases; Biochemistry; Amino acid; Cysteine; Leucine; Colorado potato beetle; Cysteine protease; Cystatin C; Enzyme; Botany; PEST analysis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002493151,0.0001087485,0.0001015399,0.00007986683,0.0002685575,0.00003086132,0.000183134,0.00009853959,0.00003717557],"category_scores_gemma":[0.0001928278,0.00007078157,0.00005404861,0.0002410709,0.00004984549,0.00001047249,0.0000373313,0.0000986192,0.00002448043],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005637624,"about_ca_system_score_gemma":0.0001669305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001674332,"about_ca_topic_score_gemma":0.0001689667,"domain_scores_codex":[0.9990102,0.0001135478,0.0002560795,0.0001971591,0.0001985731,0.0002244346],"domain_scores_gemma":[0.9989611,0.00002193114,0.0001329043,0.0001987876,0.000545146,0.0001401136],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004888321,0.00008057501,0.002569776,0.00000177508,0.00006868906,0.000005296152,0.0001704106,0.0001438271,0.9914008,0.0001688007,0.003690883,0.001210384],"study_design_scores_gemma":[0.0007531816,0.00103714,0.3239652,0.00003599383,0.00003391295,0.0001849052,0.00007656365,0.000006277254,0.6599401,0.00007574039,0.01375177,0.0001392679],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9837276,0.0001022565,0.01431643,0.001044379,0.0002186602,0.0001660808,0.0002822299,0.000006804157,0.0001355263],"genre_scores_gemma":[0.998028,0.00004420479,0.0007035842,0.0002303076,0.0002257132,0.000007189323,0.0001385324,0.000009834387,0.0006125715],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3314607,"threshold_uncertainty_score":0.2886389,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01800352547211238,"score_gpt":0.2279680461777239,"score_spread":0.2099645207056115,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}