{"id":"W2325608780","doi":"10.1038/ni.3409","title":"DNA polymerase-α regulates the activation of type I interferons through cytosolic RNA:DNA synthesis","year":2016,"lang":"en","type":"article","venue":"Nature Immunology","topic":"interferon and immune responses","field":"Immunology and Microbiology","cited_by":154,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"National Center for Advancing Translational Sciences; National Institute of Allergy and Infectious Diseases; National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; University of Texas Southwestern Medical Center","keywords":"DNA; Polymerase; DNA polymerase; Molecular biology; DNA polymerase II; Chemistry; DNA clamp; Biology; RNA; Cell biology; Biochemistry; Gene; Reverse transcriptase","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004482977,0.0006983458,0.0003244352,0.0003236845,0.0002721108,0.001137569,0.0002587383,0.0003975584,0.002199053],"category_scores_gemma":[0.0004924963,0.0002717304,0.0003594593,0.0001805618,0.000585413,0.0005720265,0.0004398352,0.0008727525,0.001547279],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001034832,"about_ca_system_score_gemma":0.0003736816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003133263,"about_ca_topic_score_gemma":0.0003737668,"domain_scores_codex":[0.9996409,0.00006094781,0.00002284623,0.000118373,0.00006482628,0.00009196273],"domain_scores_gemma":[0.9995505,0.00007072046,0.0001471989,0.00004685111,0.00007648252,0.0001082765],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004409793,0.00002144978,0.000398426,0.00007362707,0.000005342573,0.00007030672,0.00002822243,0.0001024099,0.9937596,0.0008960457,0.0001499663,0.00405368],"study_design_scores_gemma":[0.00007926506,0.0002076668,0.005546035,0.00004036108,0.00001474918,0.0003148318,0.00007454598,0.001410231,0.9863964,0.001188205,0.004717944,0.000009828294],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.906476,0.03002472,0.04176695,0.001776994,0.001428697,0.000122257,0.0009624364,0.0006756308,0.01676637],"genre_scores_gemma":[0.9864972,0.003754581,0.003267686,0.0001499113,0.0001955879,0.00002192129,0.0004436945,0.00007551827,0.005594],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002199053,"threshold_uncertainty_score":0.007508218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009647442861335702,"score_gpt":0.2487131194293222,"score_spread":0.2390656765679865,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}