{"id":"W2325675836","doi":"10.1111/xen.12222","title":"First update of the International Xenotransplantation Association consensus statement on conditions for undertaking clinical trials of porcine islet products in type 1 diabetes – Chapter 1: update on national regulatory frameworks pertinent to clinical islet xenotransplantation","year":2016,"lang":"en","type":"article","venue":"Xenotransplantation","topic":"Xenotransplantation and immune response","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"U.S. Food and Drug Administration","keywords":"Xenotransplantation; Scale (ratio); Economic shortage; Political science; Medicine; Transplantation; Geography; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.007438913,0.0003835911,0.001009673,0.0005336719,0.0001468471,0.00002662661,0.000277306,0.0004926814,0.0001989897],"category_scores_gemma":[0.003286984,0.0002719731,0.0004383687,0.0004386714,0.000159341,0.0001758777,0.00001268489,0.0004862882,0.00004227479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003540885,"about_ca_system_score_gemma":0.0003909886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002163446,"about_ca_topic_score_gemma":0.00008433668,"domain_scores_codex":[0.9930482,0.0009288958,0.00361543,0.0007054576,0.001293222,0.0004088119],"domain_scores_gemma":[0.9913049,0.005294784,0.00169174,0.0004032817,0.00116586,0.000139415],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.102828,0.005228417,0.2812676,0.002902842,0.003442215,0.00003986229,0.004639479,0.01162856,0.5231344,0.04551313,0.00834389,0.01103161],"study_design_scores_gemma":[0.02237235,0.002754669,0.6952522,0.006621268,0.001228771,0.0000218061,0.0001374044,0.001857358,0.2628906,0.00181634,0.00430502,0.0007422049],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.952391,0.00004534281,0.00335152,0.03668944,0.00195479,0.00267622,0.002660798,0.00005414627,0.0001766869],"genre_scores_gemma":[0.9920288,0.001436841,0.001383933,0.003043944,0.0003340926,0.0001271311,0.001433148,0.00005699796,0.0001550847],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4139846,"threshold_uncertainty_score":0.9999732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1138750563179217,"score_gpt":0.4199663275896918,"score_spread":0.30609127127177,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}