{"id":"W2325733949","doi":"10.1021/jm401292m","title":"Inhibition of 5-Oxo-6,8,11,14-eicosatetraenoic Acid-Induced Activation of Neutrophils and Eosinophils by Novel Indole OXE Receptor Antagonists","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Asthma and respiratory diseases","field":"Medicine","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Heart, Lung, and Blood Institute; Canadian Institutes of Health Research; Asthma Foundation","keywords":"Chemistry; Chemotaxis; Indole test; Pharmacology; Agonist; Receptor; IC50; Biochemistry; Eosinophil; Proinflammatory cytokine; Stereochemistry; In vitro; Asthma; Inflammation; Immunology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001721658,0.000368565,0.0003798087,0.0001562497,0.000116463,0.000185502,0.0002752345,0.0002028968,0.0009417807],"category_scores_gemma":[0.0001187149,0.0001537892,0.0002431932,0.0001072164,0.0001641225,0.0001429017,0.0001497486,0.0004417195,0.0003224808],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001756464,"about_ca_system_score_gemma":0.0001838421,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003137091,"about_ca_topic_score_gemma":0.00109271,"domain_scores_codex":[0.9998921,0.00002725046,0.000009228533,0.00001223918,0.00001740364,0.00004178],"domain_scores_gemma":[0.9999694,0.000006259088,0.000007676858,0.00000301896,0.000004154983,0.000009555992],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002245934,0.0001251273,0.00007099435,0.00005070366,0.00001179651,0.00006169549,0.00002146584,0.0002247965,0.9959614,0.0001337262,0.00007087589,0.003042859],"study_design_scores_gemma":[0.0003955927,0.00442823,0.00356811,0.00001852308,0.00005553479,0.0005277438,0.00004644714,0.003141986,0.9819995,0.00006792575,0.005734171,0.00001631095],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921897,0.002282567,0.0031532,0.0001022973,0.00003007479,0.00009629111,0.0002391549,0.00005743617,0.001849282],"genre_scores_gemma":[0.9900379,0.003140652,0.003653265,0.00009551557,0.00002298084,0.0000979708,0.0004971336,0.00001109808,0.002443465],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009417807,"threshold_uncertainty_score":0.003150582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01119456890224922,"score_gpt":0.2477609029299684,"score_spread":0.2365663340277191,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}