{"id":"W2325796649","doi":"10.1021/jm301303p","title":"<i>O</i><sup>2</sup>-Sulfonylethyl Protected Isopropylamine Diazen-1-ium-1,2-diolates as Nitroxyl (HNO) Donors: Synthesis, β-Elimination Fragmentation, HNO Release, Positive Inotropic Properties, and Blood Pressure Lowering Studies","year":2012,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Isopropylamine; Inotrope; Chronotropic; Sulfone; Nitroxyl; Medicinal chemistry; Pharmacology; Blood pressure; Organic chemistry; Heart rate; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009102529,0.0002912567,0.000140852,0.00006148175,0.00004777445,0.00007434948,0.0001864237,0.0001397208,0.0008219715],"category_scores_gemma":[0.00006753973,0.00005630989,0.0001112753,0.00005775059,0.0000897287,0.0001522659,0.00008414331,0.0002010229,0.0002543292],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008531444,"about_ca_system_score_gemma":0.00009619951,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001390096,"about_ca_topic_score_gemma":0.0002222925,"domain_scores_codex":[0.9999632,0.000006370439,0.000003078669,0.000007182204,0.000009042518,0.00001115834],"domain_scores_gemma":[0.999952,0.000004877893,0.00002063677,0.000003579377,0.000006991718,0.0000119104],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001154865,0.00001407008,0.00007496409,0.00004519018,0.00000244266,0.00003802946,0.000006867263,0.00006047732,0.9980159,0.00007182537,0.00003574329,0.001518977],"study_design_scores_gemma":[0.00002085576,0.0006181814,0.0008382036,0.000003843643,0.00000808916,0.0001430962,0.000007745291,0.0002146595,0.9960297,0.00001660303,0.002095605,0.000003342595],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890285,0.0024886,0.005071768,0.00004729037,0.00003866801,0.00005661034,0.0002280896,0.00006130208,0.002979172],"genre_scores_gemma":[0.9903083,0.001758716,0.005023438,0.00006192244,0.00002140113,0.00004690661,0.0003410467,0.00001735738,0.002420942],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008219715,"threshold_uncertainty_score":0.002749801,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01589634098082533,"score_gpt":0.2527761906332695,"score_spread":0.2368798496524442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}