{"id":"W2325833230","doi":"10.1038/sj.cgt.7700116","title":"Adenoviral transfer of xenogeneic MHC class I gene results in loss of tumorigenicity and inhibition of tumor growth","year":2000,"lang":"en","type":"article","venue":"Cancer Gene Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Medical Research Council; Saskatchewan Cancer Agency; University of Saskatchewan; University of Alabama at Birmingham","keywords":"Biology; Major histocompatibility complex; Immune system; MHC class I; Antigen; Immunology; Cancer research; Transfection; Tumor antigen; Cell culture; Immunotherapy; Molecular biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000363935,0.0001936856,0.0003542724,0.0001100398,0.00002603719,0.000004064046,0.0001921951,0.0001209861,0.0001131008],"category_scores_gemma":[0.000008272134,0.0001851399,0.0001076985,0.0002720105,0.0002977031,0.000007336145,0.00002136226,0.0001040589,7.962696e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003143434,"about_ca_system_score_gemma":0.0002328332,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003109533,"about_ca_topic_score_gemma":0.000371371,"domain_scores_codex":[0.9983941,0.0001583812,0.0005319023,0.0003893946,0.0002433427,0.0002829017],"domain_scores_gemma":[0.9992955,0.00001350888,0.00009429161,0.0003641379,0.0001612725,0.000071303],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01456529,0.0001652665,0.001873381,0.00004876744,0.00008258023,0.00000452384,0.0002660612,0.0003087132,0.9739194,0.000006674718,0.00002837015,0.008730967],"study_design_scores_gemma":[0.004051846,0.002722133,0.007525923,0.00003262498,0.000008958067,0.000005407654,0.00001868168,0.00002284515,0.9851518,0.00008544373,0.0002047005,0.0001696144],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9891226,0.009871408,0.00002609356,0.0001028123,0.00003008287,0.0003586997,0.0003927069,0.000004603453,0.00009102784],"genre_scores_gemma":[0.9820123,0.01747841,0.00006474366,0.0001228357,0.0001069,0.00004047942,0.00007001289,0.00003346754,0.0000708658],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01123242,"threshold_uncertainty_score":0.7549788,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01718763236942778,"score_gpt":0.2828939649167775,"score_spread":0.2657063325473497,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}