{"id":"W2325966141","doi":"10.2174/187152609787847668","title":"Sequencing of Therapy to Avoid Resistance and the Need for New Antiretroviral Drugs in the Treatment of HIV Disease","year":2009,"lang":"en","type":"review","venue":"Infectious Disorders - Drug Targets","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"","keywords":"Stavudine; Context (archaeology); Abacavir; Ritonavir; Drug resistance; Medicine; Antiretroviral therapy; Intensive care medicine; Emtricitabine; Human immunodeficiency virus (HIV); Zidovudine; Lamivudine; Virology; Pharmacology; Biology; Virus; Viral load; Genetics; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009611639,0.0008080382,0.001304876,0.001947666,0.0002218481,0.0006635256,0.0008194509,0.001038089,0.003604471],"category_scores_gemma":[0.0008285808,0.0002396731,0.000426423,0.002014574,0.0005306914,0.001319964,0.0004934796,0.001425438,0.002566415],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000594233,"about_ca_system_score_gemma":0.0009760769,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009787882,"about_ca_topic_score_gemma":0.002216438,"domain_scores_codex":[0.9996526,0.000115877,0.00004268549,0.00003728822,0.0001303141,0.00002121766],"domain_scores_gemma":[0.9996328,0.0001945184,0.00005629673,0.00001544385,0.00008129793,0.00001965073],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00003920748,0.00005123773,0.00008268739,0.008375885,0.00005182722,0.0001311404,0.00004346599,0.0003614317,0.001008733,0.002939737,0.01444666,0.972468],"study_design_scores_gemma":[0.00002488187,0.00008917144,0.0007078919,0.004132058,0.00007899857,0.001729053,0.00006755225,0.000141496,0.0006199005,0.00292216,0.9894724,0.00001438457],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001362744,0.9974247,0.00031414,0.0002838376,0.0001453803,0.000006372528,0.000007961513,0.000007142122,0.001674194],"genre_scores_gemma":[0.0007604196,0.997408,0.0006287534,0.000203393,0.00009722293,0.000007002969,0.00001887508,0.000001478264,0.0008748203],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003604471,"threshold_uncertainty_score":0.01205814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01789215056466728,"score_gpt":0.2944946303050831,"score_spread":0.2766024797404158,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}