{"id":"W2326025506","doi":"10.1021/jm401487x","title":"Chromodomain Antagonists That Target the Polycomb-Group Methyllysine Reader Protein Chromobox Homolog 7 (CBX7)","year":2014,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":108,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Drug Research and Development; University of Victoria","funders":"","keywords":"Chromodomain; Chemistry; Isothermal titration calorimetry; Biochemistry; Histone H3; Bromodomain; Lysine; Histone; Stereochemistry; Amino acid; DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001427405,0.0003720018,0.0003725324,0.0001177311,0.0001373294,0.0002505295,0.0003375734,0.000280979,0.00104338],"category_scores_gemma":[0.00007599109,0.0001096959,0.0002043321,0.00007266644,0.0002123068,0.00015775,0.0002021664,0.0008779768,0.0003538266],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003055758,"about_ca_system_score_gemma":0.0002260752,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003691606,"about_ca_topic_score_gemma":0.001427522,"domain_scores_codex":[0.9999328,0.00000793044,0.000002980215,0.00001143914,0.00002545859,0.00001938901],"domain_scores_gemma":[0.9999641,0.000006785515,0.000007941632,0.000003175988,0.000006096865,0.0000118513],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001287338,0.0001596888,0.0002546717,0.0001159715,0.00002992845,0.0001371583,0.00003182284,0.0006257601,0.9847627,0.0006185152,0.0003755758,0.0127595],"study_design_scores_gemma":[0.00013905,0.001618532,0.001019916,0.000007845166,0.0000402661,0.0005650945,0.00002224376,0.00144007,0.9813772,0.0001536949,0.01360177,0.00001439198],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9437552,0.01791266,0.02674518,0.000672793,0.0003095064,0.0006108264,0.0005559397,0.0003824089,0.009055436],"genre_scores_gemma":[0.9699506,0.007107945,0.01432477,0.0003614585,0.00005485099,0.0001957927,0.0006871858,0.00002903678,0.007288441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00104338,"threshold_uncertainty_score":0.003490448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009226477682216414,"score_gpt":0.2427087349615797,"score_spread":0.2334822572793633,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}