{"id":"W2326248627","doi":"10.1021/bm5018244","title":"Conjugation of Aurein 2.2 to HPG Yields an Antimicrobial with Better Properties","year":2015,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"PEGylation; Biocompatibility; Chemistry; Peptide; Antimicrobial; Bioconjugation; PEG ratio; Antimicrobial peptides; Combinatorial chemistry; Biochemistry; Polyethylene glycol; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000142479,0.0004811975,0.0002441308,0.0001851189,0.0001019144,0.0001998726,0.0001268727,0.0004678453,0.0008067522],"category_scores_gemma":[0.0001434864,0.0001155467,0.0002383923,0.0001692396,0.0001694177,0.000267515,0.000176135,0.0005246954,0.0003358035],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002508742,"about_ca_system_score_gemma":0.00009208965,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001712461,"about_ca_topic_score_gemma":0.0002050898,"domain_scores_codex":[0.9998842,0.00002291241,0.000009286917,0.00003112379,0.00002943865,0.00002290507],"domain_scores_gemma":[0.9998907,0.00001515506,0.00004652145,0.00001081794,0.00001528852,0.0000216284],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001713577,0.000007482022,0.00003547422,0.00001294139,0.000001681673,0.00002458479,0.000003165225,0.00004266416,0.9991056,0.00001593618,0.000009380514,0.0007239028],"study_design_scores_gemma":[0.000005468523,0.0002290668,0.001171823,0.000002113102,0.000006500773,0.0002183936,0.000003191042,0.0002840099,0.9966096,0.0000157896,0.001449593,0.000004489378],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880666,0.001786629,0.008113201,0.0001773334,0.00003799293,0.00004061491,0.0001303616,0.0000919895,0.001555252],"genre_scores_gemma":[0.9842481,0.0007911426,0.01244553,0.0001863339,0.00002704816,0.00003064748,0.0002296006,0.00003590674,0.002005654],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008067522,"threshold_uncertainty_score":0.002698839,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02810886390183669,"score_gpt":0.2314422329753035,"score_spread":0.2033333690734668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}