{"id":"W2326248627","doi":"10.1021/bm5018244","title":"Conjugation of Aurein 2.2 to HPG Yields an Antimicrobial with Better Properties","year":2015,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"PEGylation; Biocompatibility; Chemistry; Peptide; Antimicrobial; Bioconjugation; PEG ratio; Antimicrobial peptides; Combinatorial chemistry; Biochemistry; Polyethylene glycol; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001147868,0.000179394,0.0002563585,0.0001072541,0.00007990104,0.00002843762,0.0001855681,0.0001488298,0.00004824967],"category_scores_gemma":[0.00002215907,0.0001328929,0.00004612433,0.0001221855,0.0003050803,0.0001607922,0.00006818197,0.00008599656,0.0001295144],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001920196,"about_ca_system_score_gemma":0.00008236503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004752003,"about_ca_topic_score_gemma":0.0001092094,"domain_scores_codex":[0.999126,0.00009148465,0.0002152035,0.0002571694,0.0000437573,0.0002664258],"domain_scores_gemma":[0.999467,0.00001146217,0.00009722953,0.0002295116,0.0001489368,0.00004588754],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004245548,0.0001239342,0.0007170651,0.00002150755,0.00007494561,0.000007137014,0.001008469,0.00001297854,0.9901571,0.0002279406,0.005921249,0.001303077],"study_design_scores_gemma":[0.0007485951,0.0007620353,0.000798625,0.00008608215,0.00003021031,0.00007588909,0.0004871002,0.000002143628,0.9932594,0.00002790669,0.003499021,0.0002229533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997196,0.0001458571,0.0009498011,0.0006100307,0.0001890303,0.0002314984,0.00005227304,0.00006657772,0.0005589824],"genre_scores_gemma":[0.9972571,0.000002778509,0.001466733,0.0005571517,0.00004014193,0.000008759311,0.00007937053,0.0000230336,0.0005649875],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003102296,"threshold_uncertainty_score":0.5419215,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02810886390183669,"score_gpt":0.2314422329753035,"score_spread":0.2033333690734668,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}