{"id":"W2326333490","doi":"10.1128/aac.02436-15","title":"A Complex Network of Interactions between S282 and G283 of Hepatitis C Virus Nonstructural Protein 5B and the Template Strand Affects Susceptibility to Sofosbuvir and Ribavirin","year":2016,"lang":"en","type":"article","venue":"Antimicrobial Agents and Chemotherapy","topic":"Hepatitis C virus research","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta; McGill University","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research","keywords":"NS5B; Sofosbuvir; Ribavirin; Hepatitis C virus; Nucleotide; Polymerase; Virology; Context (archaeology); Hydrogen bond; DNA; Chemistry; Biology; Stereochemistry; Biochemistry; Hepacivirus; Virus; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006838654,0.0002212073,0.0001802994,0.0001087984,0.0001146958,0.0001589513,0.0001909744,0.000262784,0.001164881],"category_scores_gemma":[0.0001513574,0.0001452706,0.0001745615,0.00006871443,0.000208062,0.0001265117,0.0001442322,0.0002435505,0.0001830719],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002910996,"about_ca_system_score_gemma":0.0001760257,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001274113,"about_ca_topic_score_gemma":0.001324444,"domain_scores_codex":[0.9999264,0.00001719155,0.000004573508,0.00001346887,0.00001810651,0.00002018569],"domain_scores_gemma":[0.9999138,0.00001237739,0.00002994502,0.000003650886,0.00000484687,0.00003532937],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005806354,0.00008565684,0.002896634,0.00002066248,0.00003102608,0.0002495907,0.00002283227,0.0008225876,0.9938189,0.0001356145,0.00006715612,0.001268668],"study_design_scores_gemma":[0.0002347195,0.00149475,0.09319268,0.0000163626,0.0001138501,0.001730271,0.0001654463,0.02704132,0.8732671,0.0004791006,0.002222044,0.00004238044],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9996264,0.00007422366,0.0001090478,0.00001880174,0.00000284556,0.000002335851,0.00001974903,0.000009452125,0.0001369967],"genre_scores_gemma":[0.999673,0.00003230372,0.0001054439,0.00001562247,0.000001358249,0.000002175722,0.00003606229,0.000003481907,0.0001305937],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001274113,"threshold_uncertainty_score":0.003896952,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02825075084085657,"score_gpt":0.3111143800599053,"score_spread":0.2828636292190487,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}