{"id":"W2326394287","doi":"10.1038/sj.gt.3301534","title":"Immune-mediated destruction of transfected myocytes following DNA vaccination occurs via multiple mechanisms","year":2001,"lang":"en","type":"article","venue":"Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Medical Research Council Canada","keywords":"DNA vaccination; Biology; Immune system; Antigen; Immunology; Transfection; Major histocompatibility complex; Cell biology; Gene; Immunization; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000117324,0.0001431817,0.0001524095,0.00006465015,0.00005816277,0.000009394059,0.0001442172,0.0001405018,0.00004837866],"category_scores_gemma":[0.0000181836,0.0001371512,0.0001595293,0.0001351062,0.00001278409,0.000008611725,0.00001309078,0.00004794673,0.000007559884],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001191326,"about_ca_system_score_gemma":0.00002811368,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006842474,"about_ca_topic_score_gemma":0.00003094507,"domain_scores_codex":[0.99919,0.00005678217,0.000231629,0.0002303077,0.0001114143,0.0001798213],"domain_scores_gemma":[0.9995583,0.00001158716,0.00007756174,0.0002266329,0.00008992424,0.00003595567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003236275,0.00005437098,0.001336522,0.000002783246,0.000111069,0.000002042724,0.00007894477,0.00005159388,0.9770333,0.000003522955,0.00002005705,0.0209822],"study_design_scores_gemma":[0.001327826,0.0005682955,0.01246345,0.00000619413,0.00001297827,0.00001247915,0.00005357119,0.0002476095,0.9846562,0.0001934115,0.000306638,0.0001513339],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.965934,0.001271425,0.03221915,0.00003133718,0.0002748293,0.0001907993,0.000009810827,0.00002295477,0.00004573175],"genre_scores_gemma":[0.9971669,0.001622512,0.0006602306,0.00008124294,0.00007409964,0.00001999857,0.0002907154,0.00002031828,0.00006400288],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03155892,"threshold_uncertainty_score":0.5592864,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0104782399313062,"score_gpt":0.2340936379585872,"score_spread":0.223615398027281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}