{"id":"W2326394287","doi":"10.1038/sj.gt.3301534","title":"Immune-mediated destruction of transfected myocytes following DNA vaccination occurs via multiple mechanisms","year":2001,"lang":"en","type":"article","venue":"Gene Therapy","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"Medical Research Council Canada","keywords":"DNA vaccination; Biology; Immune system; Antigen; Immunology; Transfection; Major histocompatibility complex; Cell biology; Gene; Immunization; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00107411,0.0008162849,0.001053725,0.0006076464,0.00028589,0.0008387731,0.0005133675,0.00116975,0.001663335],"category_scores_gemma":[0.0005552065,0.0003592079,0.0008451097,0.0001705505,0.0005568078,0.0007497436,0.0007244294,0.001143335,0.0006874328],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003695489,"about_ca_system_score_gemma":0.0002066139,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001293598,"about_ca_topic_score_gemma":0.0002379457,"domain_scores_codex":[0.9990309,0.0002017149,0.00008812952,0.0001926362,0.0002455733,0.0002410156],"domain_scores_gemma":[0.9994355,0.0002138894,0.0001418126,0.00009060786,0.00007570757,0.00004250546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001580352,0.00006815256,0.0002447539,0.000121619,0.00002407649,0.00009691357,0.00004292667,0.00008106689,0.9930081,0.0009151294,0.00005830382,0.005180862],"study_design_scores_gemma":[0.00004240609,0.0004804199,0.003626035,0.00002566194,0.00004778323,0.0004879413,0.00003347966,0.001184042,0.9919357,0.0003355547,0.001790314,0.00001061569],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8869875,0.01444592,0.08583052,0.0006900246,0.0003685257,0.0005474643,0.0001703038,0.0005202912,0.01043957],"genre_scores_gemma":[0.9810978,0.003021411,0.009103574,0.0002296732,0.0001008878,0.0002706787,0.00009586511,0.00005226725,0.006027821],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001663335,"threshold_uncertainty_score":0.005680501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0104782399313062,"score_gpt":0.2340936379585872,"score_spread":0.223615398027281,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}