{"id":"W2326640045","doi":"10.1126/science.aaf5248","title":"Mitochondrial disease therapy from thin air?","year":2016,"lang":"en","type":"letter","venue":"Science","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Montreal Neurological Institute and Hospital","funders":"","keywords":"Oxidative phosphorylation; Adenosine triphosphate; Mitochondrion; Counterintuitive; Mitochondrial disease; ATP synthase; Disease; Medicine; Biology; Chemistry; Biochemistry; Bioinformatics; Cell biology; Mitochondrial DNA; Internal medicine; Gene; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001108528,0.0004837515,0.0009478282,0.0004009077,0.0006527204,0.001036099,0.0008432367,0.006519144,0.004076761],"category_scores_gemma":[0.002842417,0.0001432278,0.0007047468,0.0001912979,0.001239246,0.001963301,0.0008125977,0.008978812,0.003143786],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007091722,"about_ca_system_score_gemma":0.0004589649,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000359307,"about_ca_topic_score_gemma":0.001007791,"domain_scores_codex":[0.9996507,0.00009113039,0.00003556255,0.00004195371,0.0001370237,0.00004363361],"domain_scores_gemma":[0.9992877,0.000426469,0.00005183044,0.00004847627,0.00009069178,0.00009492098],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001541579,0.0003236116,0.0007331636,0.0006975823,0.0001269666,0.007764942,0.0001164309,0.0004414722,0.006787714,0.02964973,0.7059268,0.24589],"study_design_scores_gemma":[0.001095312,0.0007614276,0.0009193675,0.0007210503,0.00005911864,0.006256038,0.0002075759,0.0005265952,0.004007526,0.05616346,0.9292141,0.00006835513],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.006212336,0.08094686,0.001924018,0.8630278,0.03408039,0.00005771542,0.0001707161,0.0002057341,0.01337442],"genre_scores_gemma":[0.09546653,0.1281464,0.003266339,0.6215666,0.1071268,0.0003062189,0.000242801,0.000137418,0.04374091],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.006519144,"threshold_uncertainty_score":0.01363808,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01498535240121925,"score_gpt":0.2533836229084709,"score_spread":0.2383982705072517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}