{"id":"W2326643498","doi":"10.1056/nejmoa1503824","title":"Phase 3 Studies Comparing Brodalumab with Ustekinumab in Psoriasis","year":2015,"lang":"en","type":"article","venue":"New England Journal of Medicine","topic":"Psoriasis: Treatment and Pathogenesis","field":"Immunology and Microbiology","cited_by":806,"is_retracted":false,"has_abstract":true,"ca_institutions":"XLV Diagnostics (Canada); Dalhousie University; Probity Medical Research","funders":"","keywords":"Medicine; Ustekinumab; Psoriasis; Dermatology; Ixekizumab; Internal medicine; Secukinumab; Psoriatic arthritis; Disease; Infliximab","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003707445,0.0009234661,0.001864939,0.0005873644,0.0005486839,0.0009863422,0.001054042,0.001474217,0.005223445],"category_scores_gemma":[0.001698745,0.0004931556,0.002428695,0.0005346258,0.0006731562,0.0006468194,0.0003872156,0.003053544,0.0008037576],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008433605,"about_ca_system_score_gemma":0.001297413,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008420146,"about_ca_topic_score_gemma":0.002284758,"domain_scores_codex":[0.9988921,0.000652242,0.00009239913,0.0001051922,0.0001238854,0.0001342637],"domain_scores_gemma":[0.9981988,0.0006188058,0.0004306787,0.0001280295,0.0001629114,0.0004608828],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.7751151,0.04583098,0.003796126,0.002896108,0.003383053,0.0001805379,0.0002425421,0.001496548,0.03069752,0.0002807,0.003444952,0.1326358],"study_design_scores_gemma":[0.7071606,0.2759025,0.007747915,0.0001656538,0.001056575,0.0002714668,0.00003868144,0.0004563314,0.003612193,0.0001561987,0.003405693,0.00002625986],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9518762,0.03330579,0.001380198,0.001407448,0.0005373342,0.005925772,0.001309763,0.0001751914,0.00408227],"genre_scores_gemma":[0.972903,0.01407729,0.00315039,0.002335321,0.0004708841,0.003669168,0.001492067,0.00003950643,0.001862361],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005223445,"threshold_uncertainty_score":0.01960707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07908791848008138,"score_gpt":0.3240991282479725,"score_spread":0.2450112097678911,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}