{"id":"W2326666183","doi":"10.1021/jo502948t","title":"Synthesis and Properties of 2′-Deoxy-2′,4′-difluoroarabinose-Modified Nucleic Acids","year":2015,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"DNA; Chemistry; Nucleic acid; RNA; Stereochemistry; RNase H; Nucleotide; RNase P; Reverse transcriptase; Molecular biology; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005077383,0.0001703055,0.0002669447,0.00001274794,0.00004653936,0.00001501962,0.0004494862,0.0001659188,0.00005080951],"category_scores_gemma":[0.0004959335,0.0001133507,0.00008867115,0.00007315577,0.0002696932,0.000008230103,0.000173647,0.0001862027,0.000001832966],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002412168,"about_ca_system_score_gemma":0.0002014222,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002674101,"about_ca_topic_score_gemma":4.396899e-7,"domain_scores_codex":[0.9989961,0.00004107741,0.0004049428,0.000129498,0.0002528511,0.000175477],"domain_scores_gemma":[0.9988474,0.00002119837,0.0003641161,0.000363776,0.0002455159,0.0001579414],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002847484,0.00005882166,0.0003319613,0.00008692173,0.0001107993,0.000003289829,0.0001977307,0.000005235304,0.9973683,8.76829e-7,0.001109313,0.0004420091],"study_design_scores_gemma":[0.0005560407,0.00008338309,0.0001115793,0.0000683811,0.0001173896,0.0005584554,0.0008767102,0.00000865532,0.9962753,0.00003729481,0.001172123,0.000134705],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947463,0.003465367,0.00006218169,0.0002967281,0.00005901535,0.00003985933,0.000004083267,0.000005477417,0.001320957],"genre_scores_gemma":[0.9986271,0.0004368531,0.0001347981,0.00004712815,0.0002780099,0.000001050666,0.000001478401,0.00002735495,0.0004462768],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003880719,"threshold_uncertainty_score":0.4622309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570110614399919,"score_gpt":0.2133276426147804,"score_spread":0.1976265364707812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}