{"id":"W2326666183","doi":"10.1021/jo502948t","title":"Synthesis and Properties of 2′-Deoxy-2′,4′-difluoroarabinose-Modified Nucleic Acids","year":2015,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences; Natural Sciences and Engineering Research Council of Canada","keywords":"DNA; Chemistry; Nucleic acid; RNA; Stereochemistry; RNase H; Nucleotide; RNase P; Reverse transcriptase; Molecular biology; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001404694,0.0003821562,0.0001896514,0.0001309043,0.0001688396,0.0001965056,0.0002330247,0.0002911687,0.0009232624],"category_scores_gemma":[0.0002424588,0.0001404389,0.0001713749,0.000157027,0.0001145004,0.0001898216,0.00008000564,0.0003062562,0.0004659398],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00016509,"about_ca_system_score_gemma":0.0001151545,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003629812,"about_ca_topic_score_gemma":0.0005046146,"domain_scores_codex":[0.9998919,0.00002261449,0.000006460661,0.00002946348,0.00003225257,0.00001735067],"domain_scores_gemma":[0.9998688,0.00002728113,0.00003735163,0.00001672644,0.00002499083,0.00002488684],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000366416,0.00001058927,0.00008100057,0.00003171877,0.000004033065,0.00003453358,0.00002230543,0.0002216128,0.9961133,0.00009436353,0.00002093468,0.003328939],"study_design_scores_gemma":[0.000002300482,0.00009138091,0.000321448,0.000001252102,0.000004528736,0.00006883284,0.000004346226,0.0002281524,0.9972175,0.00002077758,0.002033397,0.000006023558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.975524,0.003459076,0.01745552,0.0000698649,0.00004854627,0.00005285084,0.000477095,0.0001230851,0.002789963],"genre_scores_gemma":[0.9805033,0.001415064,0.01399252,0.00004104544,0.00001935777,0.00004256535,0.0006526354,0.00004122059,0.003292287],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009232624,"threshold_uncertainty_score":0.003088653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01570110614399919,"score_gpt":0.2133276426147804,"score_spread":0.1976265364707812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}