{"id":"W2326802383","doi":"10.1021/jm2001162","title":"Preparation, Characterization, and Screening of a High Affinity Organometallic Probe for α-Adrenergic Receptors","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto; McMaster University","funders":"","keywords":"Chemistry; Receptor; Adrenergic receptor; Serotonin; Amide; 5-HT receptor; Stereochemistry; Adrenergic; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001849753,0.0002035752,0.0002479661,0.0001415585,0.0001466673,0.0002274119,0.0003374667,0.0003771121,0.00070062],"category_scores_gemma":[0.0003239237,0.0001626022,0.0001045895,0.0001107975,0.0001807416,0.0001331724,0.000138148,0.0003240155,0.0003029353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002509271,"about_ca_system_score_gemma":0.0001419814,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004364453,"about_ca_topic_score_gemma":0.0009275454,"domain_scores_codex":[0.9998827,0.00002271054,0.000009114697,0.00002514024,0.0000422239,0.00001822043],"domain_scores_gemma":[0.9998838,0.00003098898,0.00002237131,0.00001534453,0.00002457359,0.00002294363],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001542198,0.000004810543,0.00002558705,0.00001740189,0.000001609236,0.00002208284,0.000007525707,0.00003065261,0.9993242,0.00002298679,0.00001243716,0.0005153601],"study_design_scores_gemma":[0.00001711628,0.000186348,0.0004571691,0.000002930502,0.00001022027,0.0003665483,0.00001343055,0.0004564494,0.996389,0.0000212575,0.002074694,0.00000485392],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9663668,0.002754669,0.02729025,0.000218021,0.00003322386,0.0001885231,0.0002836152,0.0001865817,0.002678252],"genre_scores_gemma":[0.9769582,0.001087853,0.01821125,0.00007483413,0.00001354223,0.00007327691,0.0004741407,0.00003261171,0.003074385],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00070062,"threshold_uncertainty_score":0.002343833,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04221889560178221,"score_gpt":0.3083912520441248,"score_spread":0.2661723564423426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}