{"id":"W2326802383","doi":"10.1021/jm2001162","title":"Preparation, Characterization, and Screening of a High Affinity Organometallic Probe for α-Adrenergic Receptors","year":2011,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Addiction and Mental Health; University of Toronto; McMaster University","funders":"","keywords":"Chemistry; Receptor; Adrenergic receptor; Serotonin; Amide; 5-HT receptor; Stereochemistry; Adrenergic; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003100931,0.0001097606,0.0003396111,0.00003164259,0.00004693656,0.000004443228,0.00009211468,0.00009387769,0.0003846427],"category_scores_gemma":[0.0002910717,0.00008844118,0.00007719958,0.0001526577,0.0001408689,0.0000781946,0.00001458545,0.0001905586,3.024843e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002210821,"about_ca_system_score_gemma":0.0001250788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001511236,"about_ca_topic_score_gemma":4.948971e-8,"domain_scores_codex":[0.9989833,0.000009538417,0.0005459605,0.0001245942,0.0002203244,0.000116238],"domain_scores_gemma":[0.998712,0.00005788667,0.0004766179,0.0001234952,0.0004051696,0.0002248205],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007757113,0.0002077524,0.001975589,0.0005936312,0.0001194077,0.00000592037,0.0002643125,8.190135e-7,0.9934775,0.00007259272,0.0001294124,0.002377407],"study_design_scores_gemma":[0.001756002,0.0002596535,0.00863072,0.0002400813,0.0003687858,0.0004704558,0.000137819,0.00005720328,0.9853179,0.0001928329,0.002482674,0.00008583016],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9784632,0.0002288388,0.02017787,0.0004728369,0.00004226813,0.000153617,0.000009806699,0.000009391396,0.0004421294],"genre_scores_gemma":[0.9896576,0.0001288132,0.009196237,0.0000749144,0.0004103957,0.00001163188,0.00003740323,0.00001211714,0.0004709079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01119434,"threshold_uncertainty_score":0.4211568,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04221889560178221,"score_gpt":0.3083912520441248,"score_spread":0.2661723564423426,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}