{"id":"W2326948553","doi":"10.3899/jrheum.110874","title":"Efficacy and Safety of CE-224,535, an Antagonist of P2X<sub>7</sub>Receptor, in Treatment of Patients with Rheumatoid Arthritis Inadequately Controlled by Methotrexate","year":2012,"lang":"en","type":"article","venue":"The Journal of Rheumatology","topic":"Adenosine and Purinergic Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":238,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Pfizer","keywords":"Medicine; Placebo; Rheumatoid arthritis; Internal medicine; Adverse effect; Rheumatology; Methotrexate; Clinical endpoint; Nausea; Arthritis; Gastroenterology; Randomized controlled trial; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000512884,0.0001784571,0.0008298255,0.00008618189,0.00003767273,0.000003029624,0.0001465929,0.0001192981,0.00001010115],"category_scores_gemma":[0.00007872684,0.0001113252,0.000082813,0.00008718699,0.0002413999,0.00001568423,0.00003376812,0.00008654023,2.947932e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001349458,"about_ca_system_score_gemma":0.00007449757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001198285,"about_ca_topic_score_gemma":0.00001973782,"domain_scores_codex":[0.9982538,0.0004219156,0.0008454011,0.0001057295,0.0001465032,0.0002266106],"domain_scores_gemma":[0.9983359,0.0001833144,0.001037872,0.0001877696,0.0001654219,0.00008971228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.02437519,0.001944803,0.5009936,0.00006416316,0.0008252267,0.000001908403,0.001555709,0.0001457191,0.4612853,0.0001145837,0.000344524,0.008349264],"study_design_scores_gemma":[0.05130814,0.008745496,0.04661903,0.0003542934,0.0001705375,0.0005131364,0.0006465588,0.00003224907,0.8902844,0.00004434716,0.0009392281,0.0003425664],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9855072,0.01382856,0.0002790229,0.00005051267,0.00006666031,0.0002151745,0.00003195433,0.000001331931,0.0000195596],"genre_scores_gemma":[0.9809456,0.0187656,0.0002202805,0.000009328173,0.000007742951,0.000002818556,0.00002956739,0.00001633502,0.000002759757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4543746,"threshold_uncertainty_score":0.4539709,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007212974894057878,"score_gpt":0.2303127607684511,"score_spread":0.2230997858743933,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}