{"id":"W2327002222","doi":"10.1093/neuonc/nov061.91","title":"MB-15 * ACTIVATED Wnt SIGNALING TARGETS Sox2+ TREATMENT-REFRACTORY Shh-DEPENDENT MEDULLOBLASTOMA STEM CELLS","year":2015,"lang":"en","type":"article","venue":"Neuro-Oncology","topic":"MicroRNA in disease regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"","keywords":"Medulloblastoma; SOX2; Wnt signaling pathway; Cancer research; Stem cell; Refractory (planetary science); Chemistry; Cell biology; Biology; Signal transduction; Biochemistry; Transcription factor; Astrobiology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001682185,0.0001825916,0.0003307604,0.0001814371,0.0001109747,0.0003394577,0.000149615,0.0001687411,0.001030853],"category_scores_gemma":[0.0001128177,0.0001185813,0.000238446,0.0001164386,0.0001199915,0.00008625896,0.000133419,0.0004072286,0.0003919082],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002366287,"about_ca_system_score_gemma":0.0002302765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001704365,"about_ca_topic_score_gemma":0.003316712,"domain_scores_codex":[0.9998478,0.00002168716,0.0000227594,0.00002833787,0.00004549686,0.00003389901],"domain_scores_gemma":[0.999926,0.00001455391,0.00001596316,0.00001242751,0.000007114931,0.00002391168],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002229841,0.0001755493,0.001198421,0.00004772105,0.00001241343,0.00008650839,0.00004592144,0.0002232444,0.9942377,0.0001342635,0.0002107581,0.003404528],"study_design_scores_gemma":[0.00006711617,0.002311252,0.01756844,0.000008794922,0.00003809647,0.0005117041,0.00005429736,0.002048808,0.9714223,0.00004121466,0.005922329,0.000005634539],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970029,0.0005401715,0.0007298294,0.00004765549,0.000012851,0.00007803921,0.0004829918,0.0000492762,0.00105637],"genre_scores_gemma":[0.9955953,0.0003178927,0.0009795465,0.00004275195,0.000004807594,0.00005517307,0.001070051,0.00001210564,0.001922295],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001704365,"threshold_uncertainty_score":0.003448606,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02224597898360645,"score_gpt":0.2718528396064959,"score_spread":0.2496068606228894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}