{"id":"W2327031434","doi":"10.1158/1538-7445.am10-3578","title":"Abstract 3578: New Angiochem-modified doxorubicin with increased brain penetration and efficacy against brain tumors","year":2010,"lang":"en","type":"article","venue":"Cancer Research","topic":"Nanoplatforms for cancer theranostics","field":"Engineering","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université du Québec à Montréal; Université de Montréal; Angiochem (Canada)","funders":"","keywords":"Doxorubicin; Blood–brain barrier; Paclitaxel; Medicine; Pharmacology; Drug; Peptide; Cancer research; Efflux; Chemotherapy; Chemistry; Internal medicine; Biochemistry; Central nervous system","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008383551,0.0002805128,0.0001765336,0.0001937397,0.00006834481,0.000176036,0.0001534522,0.0002247856,0.001165472],"category_scores_gemma":[0.00007219242,0.00008066423,0.0001148184,0.00007796265,0.0001234226,0.0001729965,0.00009687492,0.0002815022,0.0003477974],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002508909,"about_ca_system_score_gemma":0.0001269931,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004768785,"about_ca_topic_score_gemma":0.0005582692,"domain_scores_codex":[0.9999554,0.00000764618,0.000002745078,0.00001130716,0.00001218333,0.00001074608],"domain_scores_gemma":[0.9999537,0.000009051052,0.00001017822,0.000003867244,0.000005908287,0.00001719438],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001940944,0.0001153223,0.0001006125,0.00004447861,0.000006634475,0.0001080635,0.00001450668,0.0001780538,0.9945087,0.0001230768,0.0001577888,0.004448671],"study_design_scores_gemma":[0.0001841377,0.003283689,0.003033888,0.00000671202,0.00002803899,0.0004368632,0.000006667462,0.001495,0.9864174,0.00003575627,0.005061664,0.00001021864],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944549,0.001060697,0.001595005,0.00007850565,0.00004025301,0.00006170248,0.0001709563,0.00006736651,0.002470554],"genre_scores_gemma":[0.9934307,0.0006544441,0.002530823,0.00007475857,0.00001872084,0.00004149663,0.0003015323,0.00001982349,0.002927745],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001165472,"threshold_uncertainty_score":0.003898919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02944761128297296,"score_gpt":0.3161238917802913,"score_spread":0.2866762804973184,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}