{"id":"W2327106913","doi":"10.1158/0008-5472.sabcs11-p1-12-25","title":"P1-12-25: Evaluation of PTEN, EGFR and Ki67 Expression as Predictors of Response to a Trastuzumab-Containing Neoadjuvant Chemotherapy Regimen in a HER-2 Over-Expressing Locally Advanced Breast Cancer (LABC) Trial.","year":2011,"lang":"en","type":"article","venue":"Cancer Research","topic":"Breast Cancer Treatment Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"","keywords":"Trastuzumab; Medicine; PTEN; Breast cancer; Oncology; Docetaxel; Regimen; Epirubicin; Internal medicine; Chemotherapy; Tissue microarray; Carboplatin; Neoadjuvant therapy; Immunohistochemistry; Cancer; Cisplatin; Biology; PI3K/AKT/mTOR pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001601006,0.0007400206,0.0009161556,0.0002412726,0.0001727265,0.0006781882,0.0004387351,0.0006279902,0.001303138],"category_scores_gemma":[0.001112132,0.000213522,0.0003930889,0.000271429,0.000408393,0.0002742823,0.0002204987,0.001221084,0.0002805285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004684033,"about_ca_system_score_gemma":0.0008846296,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005884705,"about_ca_topic_score_gemma":0.001144225,"domain_scores_codex":[0.9996741,0.00019701,0.00001362085,0.00005056268,0.00003105647,0.00003370273],"domain_scores_gemma":[0.9992194,0.0002272906,0.0001490976,0.00003087023,0.00004400883,0.0003293698],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.7600238,0.01604539,0.116615,0.0004907575,0.001076567,0.0004069555,0.0001738118,0.002677124,0.02866563,0.00008480197,0.00160677,0.07213344],"study_design_scores_gemma":[0.2253537,0.5250673,0.2279334,0.00008216633,0.001875596,0.0007680868,0.0001095936,0.007450937,0.008868617,0.0001699393,0.002261504,0.00005919495],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983888,0.0007679626,0.00007920268,0.00009356622,0.00001004042,0.0002406659,0.0001860401,0.00001350932,0.0002203522],"genre_scores_gemma":[0.9974598,0.0003010158,0.0004542537,0.0001117578,0.00003342148,0.0003907755,0.000829339,0.000004687479,0.0004149583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001601006,"threshold_uncertainty_score":0.008467078,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06200430170921554,"score_gpt":0.3939882848043629,"score_spread":0.3319839830951473,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}