{"id":"W2327114611","doi":"10.1021/ja109377p","title":"HIV Protease-Mediated Activation of Sterically Capped Proteasome Inhibitors and Substrates","year":2010,"lang":"en","type":"article","venue":"Journal of the American Chemical Society","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Proteasome; Protease; HIV-1 protease; Small molecule; Human immunodeficiency virus (HIV); Cell biology; Biochemistry; Virology; Enzyme; Biology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001721418,0.00031145,0.0002308815,0.00007342654,0.000120791,0.0003385554,0.0002729568,0.0003244584,0.001009012],"category_scores_gemma":[0.0001730308,0.0001148786,0.0001636336,0.00008064954,0.0002502066,0.0002248079,0.0002098541,0.0004801452,0.0002473618],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002580158,"about_ca_system_score_gemma":0.0001733305,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001055761,"about_ca_topic_score_gemma":0.0002183782,"domain_scores_codex":[0.9998455,0.00002792211,0.00001173506,0.00003458525,0.00004363674,0.00003668252],"domain_scores_gemma":[0.999925,0.00001640424,0.00002648969,0.00000984591,0.00000832033,0.00001393005],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006970188,0.00001342898,0.00002877679,0.00003951251,0.000003281523,0.00006611121,0.000009811383,0.0001483701,0.9975445,0.000708822,0.00004807918,0.00131958],"study_design_scores_gemma":[0.00001203683,0.00009520207,0.0001163446,0.000001698522,0.00000332466,0.0000982183,0.000002948001,0.0004010698,0.9974335,0.00005173274,0.001781737,0.000002219289],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9684716,0.003927593,0.02154542,0.0002378479,0.0001077896,0.0001026686,0.0001774567,0.0001965878,0.005232881],"genre_scores_gemma":[0.9900593,0.0009270543,0.005939865,0.00007583087,0.00001740429,0.00004617931,0.0001380365,0.00002083387,0.002775573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001009012,"threshold_uncertainty_score":0.003375471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007824631384684507,"score_gpt":0.24254457425593,"score_spread":0.2347199428712455,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}