{"id":"W2327170312","doi":"10.1021/bi300663r","title":"The Catalytic Serine of <i>meta</i>-Cleavage Product Hydrolases Is Activated Differently for C–O Bond Cleavage Than for C–C Bond Cleavage","year":2012,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Enzyme kinetics; Nucleophile; Bond cleavage; Hydrolysis; Catalysis; Methanol; Stereochemistry; Catalytic triad; Medicinal chemistry; Organic chemistry; Active site","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003441941,0.0003568479,0.0003892788,0.00002816994,0.0002245814,0.00004419622,0.0003829084,0.0002177536,0.0000044118],"category_scores_gemma":[0.000357728,0.000267354,0.0004350488,0.0001468644,0.0001771468,0.00001970789,0.0001479707,0.00009252133,0.000002609477],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002797493,"about_ca_system_score_gemma":0.00007193314,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009856515,"about_ca_topic_score_gemma":0.000006014564,"domain_scores_codex":[0.998247,0.00001638131,0.0004597291,0.0005525014,0.0001828862,0.0005414807],"domain_scores_gemma":[0.9983366,0.00007584478,0.0003319686,0.0009530603,0.0001560704,0.000146423],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002905217,0.0002156003,0.0004204685,0.0002815836,0.0004885933,1.199123e-7,0.00004239815,6.509166e-7,0.9307814,0.00002403779,0.06701304,0.0004415558],"study_design_scores_gemma":[0.0007065469,0.0001845242,0.0003936164,0.00001906846,0.0004663116,0.000007243772,0.0001278026,0.00001502553,0.9677714,0.00001882979,0.02997481,0.0003148565],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9907295,0.005977483,0.0004849832,0.0002460185,0.0001997611,0.0009030671,0.0006691064,0.00002773968,0.000762401],"genre_scores_gemma":[0.9942989,0.0002531518,0.0003645589,0.0001279009,0.0005684343,0.0002816224,0.001858601,0.00007176034,0.002175056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03703823,"threshold_uncertainty_score":0.9999779,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01747588155247441,"score_gpt":0.2562158650488048,"score_spread":0.2387399834963304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}