{"id":"W2327170312","doi":"10.1021/bi300663r","title":"The Catalytic Serine of <i>meta</i>-Cleavage Product Hydrolases Is Activated Differently for C–O Bond Cleavage Than for C–C Bond Cleavage","year":2012,"lang":"en","type":"article","venue":"Biochemistry","topic":"Enzyme Catalysis and Immobilization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Enzyme kinetics; Nucleophile; Bond cleavage; Hydrolysis; Catalysis; Methanol; Stereochemistry; Catalytic triad; Medicinal chemistry; Organic chemistry; Active site","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001709142,0.0004679151,0.0003991828,0.0001108686,0.0001490538,0.0008457623,0.000392679,0.000465233,0.00147902],"category_scores_gemma":[0.0002861376,0.0002613654,0.0006091781,0.0001393161,0.0003366258,0.0005911615,0.0002514436,0.0005069354,0.001080594],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004150945,"about_ca_system_score_gemma":0.0002774045,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003643516,"about_ca_topic_score_gemma":0.0002596334,"domain_scores_codex":[0.9997417,0.00002633886,0.00002393773,0.00009807864,0.00005394893,0.00005590719],"domain_scores_gemma":[0.999858,0.00002429747,0.00004275015,0.00001864466,0.00002604812,0.00003006599],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001838894,0.00001059379,0.0007008673,0.00004332551,0.00001078056,0.00006582322,0.00001445831,0.00007253901,0.9963297,0.0002013311,0.00004794499,0.002318773],"study_design_scores_gemma":[0.00001509192,0.0001383681,0.006736453,0.000005389059,0.00001471252,0.0004736501,0.0000273885,0.0008986045,0.9892305,0.0001392019,0.002308944,0.00001165412],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9810793,0.002079891,0.01199502,0.0001968896,0.00007543538,0.00003050881,0.000424304,0.0002163791,0.003902249],"genre_scores_gemma":[0.9923899,0.0007140853,0.00408384,0.0001034864,0.00002152521,0.00002020894,0.0008298997,0.00006730462,0.001769723],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00147902,"threshold_uncertainty_score":0.004947841,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01747588155247441,"score_gpt":0.2562158650488048,"score_spread":0.2387399834963304,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}