{"id":"W2327241189","doi":"10.1021/jm401153j","title":"Development and Pharmacological Characterization of Conformationally Constrained Urotensin II-Related Peptide Agonists","year":2013,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Cardiovascular, Neuropeptides, and Oxidative Stress Research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; PROTEO; Institut National de la Recherche Scientifique","funders":"Fonds de Recherche du Québec - Santé; Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Chemistry; Urotensin-II; Peptide; Pharmacology; Stereochemistry; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00045459,0.0001264245,0.000439017,0.00007216935,0.0000640567,0.00001258189,0.00008035747,0.0000857184,0.0007182072],"category_scores_gemma":[0.0003271382,0.00009167031,0.0001139312,0.0001071115,0.000287936,0.0001164906,0.00004955709,0.0004053213,0.000004302975],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000540333,"about_ca_system_score_gemma":0.0003364482,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002576337,"about_ca_topic_score_gemma":5.285825e-8,"domain_scores_codex":[0.9982725,0.00003542355,0.0007046085,0.0001063239,0.0007182843,0.0001628573],"domain_scores_gemma":[0.9983689,0.0000584728,0.0003792717,0.00007689271,0.0008556761,0.0002607803],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001977358,0.0000772836,0.0004987919,0.0002189783,0.0003597542,0.0001604134,0.0003546789,0.000001330155,0.9783765,0.00000475508,0.0002338238,0.01951597],"study_design_scores_gemma":[0.00606549,0.0003951658,0.1396258,0.0007181115,0.0002747705,0.005754382,0.0005722271,0.0002790046,0.8371771,0.00001851035,0.008954635,0.0001647373],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953316,0.0002269342,0.0001321924,0.0007933757,0.00005173348,0.0001752484,0.000003631357,0.000007056333,0.003278235],"genre_scores_gemma":[0.9978501,0.0002837471,0.0008980578,0.0001700153,0.0001652418,0.000002351982,0.00003955255,0.000008673666,0.0005822559],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1411994,"threshold_uncertainty_score":0.7863865,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0173295332051656,"score_gpt":0.2704197618603054,"score_spread":0.2530902286551397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}